Izzo, Valentina (2013) New strategies for the study of celiac disease genetics. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: New strategies for the study of celiac disease genetics
Creators:
CreatorsEmail
Izzo, Valentinavalent.izzo@gmail.com
Date: 31 March 2013
Number of Pages: 108
Institution: Università degli Studi di Napoli Federico II
Department: Pediatria
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Riproduzione, sviluppo e accrescimento dell'uomo
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Pignata, Claudioclaudio.pignata@unina.it
Tutor:
nomeemail
Greco, Luigiydongre@unina.it
Date: 31 March 2013
Number of Pages: 108
Uncontrolled Keywords: Celiachia, genetica
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/03 - Genetica medica
Area 06 - Scienze mediche > MED/12 - Gastroenterologia
Aree tematiche (7° programma Quadro): SALUTE e TUTELA DEL CONSUMATORE > Ottimizzazione per la prestazione delle cure sanitarie per i cittadini in Europa
Date Deposited: 11 Apr 2013 11:38
Last Modified: 31 Dec 2016 02:00
URI: http://www.fedoa.unina.it/id/eprint/9099

Abstract

Celiac Disease (CD) is a chronic enterophaty affecting the small intestine and triggered by gluten proteins contained in wheat, barley and rye. It is characterized by an autoimmune response in genetically susceptible individuals, and only the 40% of the genetics is explained by HLA predisposition. Recently, several susceptibility loci not HLA related have been identified by genome-wide association studies (GWAs). Our aim is to extract as many information as we can from the large amount of data emerged from these studies. The critic analysis of the large panorama of CD candidate genes leads to consider several mechanisms of action that may have gone unnoticed if we persist in considering all the genes together. Whereas, analyzing a small set of genes from different points of view it is possible to really understand why this more than the other gene resulted to be associated with the disease. GWAs made the history of complex diseases, but represent only the starting point from which postulate hypothesis, mechanisms of action, interactions, in order to untangle the skein represented by the complex pathogenesis of celiac disease.

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