Somma, Domenico (2013) CIKS/DDX3X interaction controls the stability of Zc3h12a mRNA induced by IL-17. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: CIKS/DDX3X interaction controls the stability of Zc3h12a mRNA induced by IL-17
Creators:
CreatorsEmail
Somma, Domenicodomenico.somma@unina.it
Date: 2 April 2013
Number of Pages: 71
Institution: Università degli Studi di Napoli Federico II
Department: Biologia e patologia cellullare e molecolare "L. Califano"
Scuola di dottorato: Medicina molecolare
Dottorato: Oncologia ed endocrinologia molecolare
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Santoro, Massimomassimo.santoro@unina.it
Tutor:
nomeemail
Leonardi, Antonioleonardi@unina.it
Date: 2 April 2013
Number of Pages: 71
Uncontrolled Keywords: IL-17 DDX3X CIKS
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 06 - Scienze mediche > MED/04 - Patologia generale
Aree tematiche (7° programma Quadro): SALUTE e TUTELA DEL CONSUMATORE > Ottimizzazione per la prestazione delle cure sanitarie per i cittadini in Europa
Date Deposited: 11 Apr 2013 14:08
Last Modified: 15 Jul 2014 13:16
URI: http://www.fedoa.unina.it/id/eprint/9447

Abstract

Interleukin 17 (IL-17) promotes the expression of cytokines and proteins involved in inflammation response via the induction of gene transcription and post-transcriptional stabilization of mRNA. We show here that IL-17 enhanced the stability of zc3h12a mRNA through the RNA binding protein DDX3X. After receptor triggering DDX3X binds the ubiquitin ligase CIKS trough the helicase domain and stabilize zc3h12a mRNA by directly binding the mRNA. This process involved CIKS (but the E3 ubiquitin ligase function is dispensable) the adaptors TRAF2 and TRAF5, and the kinase IKKε. Zc3h12a is an endonuclease involved in controlling inflammatory responses by degrading mRNA of some inflammatory protein such as IL-6. This effect is important to correctly switch-off the IL-17-dependent inflammation.

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