Barbieri, Mariano
(2013)
Statistical Mechanics Models of Chromatin Architecture.
[Tesi di dottorato]
| Item Type: |
Tesi di dottorato
|
| Lingua: |
English |
| Title: |
Statistical Mechanics Models of Chromatin Architecture |
| Creators: |
| Creators | Email |
|---|
| Barbieri, Mariano | mariano.barbieri@gmail.com |
|
| Date: |
2 April 2013 |
| Number of Pages: |
64 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Fisica |
| Scuola di dottorato: |
Scienze fisiche |
| Dottorato: |
Fisica fondamentale ed applicata |
| Ciclo di dottorato: |
25 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Velotta, Raffaele | velotta@na.infn.it |
|
| Tutor: |
| nome | email |
|---|
| Nicodemi, Mario | nicodem@na.infn.it |
|
| Date: |
2 April 2013 |
| Number of Pages: |
64 |
| Uncontrolled Keywords: |
genome organization,genome architecture,long-range chromatin
interactions,fluorescence in situ hybridization,Monte Carlo simulation |
| Settori scientifico-disciplinari del MIUR: |
Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici
Area 02 - Scienze fisiche > FIS/07 - Fisica applicata (a beni culturali, ambientali, biologia e medicina) |
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| Date Deposited: |
09 Apr 2013 14:00 |
| Last Modified: |
18 Jul 2014 10:12 |
| URI: |
http://www.fedoa.unina.it/id/eprint/9492 |
| DOI: |
10.6092/UNINA/FEDOA/9492 |
Abstract
We considered phenomena that recent quantitative biological data are unveiling to happen in cell nucleus, by means of Statistical Mechanics tools.
In particular we focused on genome spatial self-organization, and its striking connection with genetic expression process, hence with future perspective on disease studies.
We lead our research efforts starting from biological data obtained by a direct collaboration with Ana Pombo's biologists group of London Imperial College and her working group.
I've statistically characterized our proposed model for genome self-organization by means of massive Motecarlo Simulations. Furthermore I've analitically characterized a model predicting Symmetry Breaking mechanism for some observed phenomenologies into the nucleus.
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