Barbieri, Mariano (2013) Statistical Mechanics Models of Chromatin Architecture. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Statistical Mechanics Models of Chromatin Architecture
Creators:
CreatorsEmail
Barbieri, Marianomariano.barbieri@gmail.com
Date: 2 April 2013
Number of Pages: 64
Institution: Università degli Studi di Napoli Federico II
Department: Fisica
Scuola di dottorato: Scienze fisiche
Dottorato: Fisica fondamentale ed applicata
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Velotta, Raffaelevelotta@na.infn.it
Tutor:
nomeemail
Nicodemi, Marionicodem@na.infn.it
Date: 2 April 2013
Number of Pages: 64
Uncontrolled Keywords: genome organization,genome architecture,long-range chromatin interactions,fluorescence in situ hybridization,Monte Carlo simulation
Settori scientifico-disciplinari del MIUR: Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici
Area 02 - Scienze fisiche > FIS/07 - Fisica applicata (a beni culturali, ambientali, biologia e medicina)
Date Deposited: 09 Apr 2013 14:00
Last Modified: 18 Jul 2014 10:12
URI: http://www.fedoa.unina.it/id/eprint/9492
DOI: 10.6092/UNINA/FEDOA/9492

Abstract

We considered phenomena that recent quantitative biological data are unveiling to happen in cell nucleus, by means of Statistical Mechanics tools. In particular we focused on genome spatial self-organization, and its striking connection with genetic expression process, hence with future perspective on disease studies. We lead our research efforts starting from biological data obtained by a direct collaboration with Ana Pombo's biologists group of London Imperial College and her working group. I've statistically characterized our proposed model for genome self-organization by means of massive Motecarlo Simulations. Furthermore I've analitically characterized a model predicting Symmetry Breaking mechanism for some observed phenomenologies into the nucleus.

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