Vettori, Serena (2013) miR-145 is a key regulator of the TGF-β signaling pathway in systemic sclerosis and counteracts experimental fibrosis. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: miR-145 is a key regulator of the TGF-β signaling pathway in systemic sclerosis and counteracts experimental fibrosis
Creators:
CreatorsEmail
Vettori, Serenaserenavettori@libero.it
Date: 2 April 2013
Number of Pages: 22
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Fisiopatologia clinica e medicina sperimentale
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Marone, Giannimarone@unina.it
Tutor:
nomeemail
De Paulis, Amatodepaulis@unina.it
Date: 2 April 2013
Number of Pages: 22
Uncontrolled Keywords: microRNA, miR-145, systemic sclerosis, fibrosis
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 06 - Scienze mediche > MED/16 - Reumatologia
Date Deposited: 11 Apr 2013 09:27
Last Modified: 17 Jun 2014 06:05
URI: http://www.fedoa.unina.it/id/eprint/9537

Abstract

microRNAs (miRNAs) are key regulators of different basic cellular processes. A number of miRNAs have been found to be dysregulated in many disease settings, most notably cancers. The role of miRNAs in systemic sclerosis (SSc), as well as in other fibrotic disorders has been scarcely investigated. Here we analyzed miRNA expression profile in SSc and identified miR-145 as a deeply down-regulated miRNA in SSc dermal fibroblasts and skin, which plays a crucial role in the regulation of the TGF-beta pathway in vitro and in vivo.

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