Vettori, Serena (2013) miR-145 is a key regulator of the TGF-β signaling pathway in systemic sclerosis and counteracts experimental fibrosis. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | miR-145 is a key regulator of the TGF-β signaling pathway in systemic sclerosis and counteracts experimental fibrosis |
| Creators: | Creators Email Vettori, Serena serenavettori@libero.it |
| Date: | 2 April 2013 |
| Number of Pages: | 22 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Scienze Mediche Traslazionali |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Fisiopatologia clinica e medicina sperimentale |
| Ciclo di dottorato: | 25 |
| Coordinatore del Corso di dottorato: | nome email Marone, Gianni marone@unina.it |
| Tutor: | nome email De Paulis, Amato depaulis@unina.it |
| Date: | 2 April 2013 |
| Number of Pages: | 22 |
| Keywords: | microRNA, miR-145, systemic sclerosis, fibrosis |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 06 - Scienze mediche > MED/16 - Reumatologia |
| Date Deposited: | 11 Apr 2013 09:27 |
| Last Modified: | 17 Jun 2014 06:05 |
| URI: | http://www.fedoa.unina.it/id/eprint/9537 |
Collection description
microRNAs (miRNAs) are key regulators of different basic cellular processes. A number of miRNAs have been found to be dysregulated in many disease settings, most notably cancers. The role of miRNAs in systemic sclerosis (SSc), as well as in other fibrotic disorders has been scarcely investigated. Here we analyzed miRNA expression profile in SSc and identified miR-145 as a deeply down-regulated miRNA in SSc dermal fibroblasts and skin, which plays a crucial role in the regulation of the TGF-beta pathway in vitro and in vivo.
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