Ucci, Valentina (2013) 5-HT2a receptor pathway in oligodendrocyte differentiation: its involvement in Multiple Sclerosis pathogenesis. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | 5-HT2a receptor pathway in oligodendrocyte differentiation: its involvement in Multiple Sclerosis pathogenesis |
| Autori: | Autore Email Ucci, Valentina [non definito] |
| Data: | 11 Aprile 2013 |
| Numero di pagine: | 88 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Molecolare e Biotecnologie Mediche |
| Scuola di dottorato: | Medicina molecolare |
| Dottorato: | Patologia e fisiopatologia molecolare |
| Ciclo di dottorato: | 25 |
| Coordinatore del Corso di dottorato: | nome email Avvedimento, Vittorio Enrico avvedim@unina.it |
| Tutor: | nome email Santillo, Maria Rosaria marsanti@unina.it |
| Data: | 11 Aprile 2013 |
| Numero di pagine: | 88 |
| Parole chiave: | Multiple sclerosis- Differentiation-Oligondedrocytes |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/04 - Patologia generale Area 06 - Scienze mediche > MED/09 - Medicina interna |
| Depositato il: | 11 Apr 2013 14:11 |
| Ultima modifica: | 08 Mag 2016 01:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/9563 |
Abstract
Multiple sclerosis (MS) is a chronic demyelinating disease affecting the neurons of brain and spinal cord. In chronic MS lesions oligodendrocytes (the myelin synthesizing cells) precursor cells (OPCs) accumulate with loss of mature OLs, suggesting a differentiation block of OPCs. In MS patients during the active phase of the disease (poussè) the disruption of the blood brain barrier can allow serum antibodies and other molecules to reach the CNS, producing demyelination. Here we demonstrate that IgGs, isolated from MS patients during the acute phase, inhibit PMA-induced differentiation of OPCs by reducing the expression of the OLs differentiation markers in the human OL cell line, MO3-13. In a more specific setting, we found that IgGs from MS patients inhibit differentiation driven by P-ERK activation, The identification of a putative receptor targeted by IgGs present in the biological fluids of MS patients will pave the way to dissect the ERK1/2-dependent signalling pathway leading to demyelination in MS.
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