Salzano, Giuseppina (2014) Development of new self-assembling nanoparticles for the delivery of active agents for the treatment of tumors. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Development of new self-assembling nanoparticles for the delivery of active agents for the treatment of tumors
Creators:
CreatorsEmail
Salzano, Giuseppinagiuseppina.salzano@unina.it
Date: 28 March 2014
Number of Pages: 111
Institution: Università degli Studi di Napoli Federico II
Department: Farmacia
Scuola di dottorato: Scienze farmaceutiche
Dottorato: Scienza del farmaco
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
De Rosa, GiuseppeUNSPECIFIED
Date: 28 March 2014
Number of Pages: 111
Uncontrolled Keywords: Self-assembly;Nanoparticles;Cancer treatment
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/09 - Farmaceutico tecnologico applicativo
Aree tematiche (7° programma Quadro): NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Nanoscienze e Nanotecnologie
Date Deposited: 07 Apr 2014 09:45
Last Modified: 26 Jan 2015 12:23
URI: http://www.fedoa.unina.it/id/eprint/9743

Abstract

The research activity done during the three years of my Doctorate was focused on the development of new self-assembling formulations based on nanotechnology for the delivery of active agents in tumors. In particular, the research activity was articulated on two main projects: 1. Design of self-assembling nanoparticles (NPs) functionalized with human transferrin for the delivery of zoledronic acid in brain tumors. 2. Development of multifunctional polymeric micelles for the co-delivery of an anti-survivin siRNA and Paclitaxel for the reversal of drug resistance in ovarian cancer. In both projects, we proposed and developed particularly promising approaches which combined in one “ultimate NP” several advantages. In particular, in all the cases, we developed “easy to obtain” NPs characterized by optimal physical proprieties, such as a high incorporation efficiency of the active agents and size suitable to use the NPs for cancer therapy. Interestingly, a significant inhibition of the cell growth and marked biological effects were observed in different cancer cells by using the developed NPs. Furthermore, the developed NPs elicited a significant inhibition of the tumor growth in xenografted animal models of different tumors superior compared to the one observed after treatment with free active agents.

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