Di Costanzo, Luisa (2014) Psoriasis and melanogenesis: which differences between psoriatic and healthy skin? [Tesi di dottorato]
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DI COSTANZO_LUISA_26.pdf Download (7MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Psoriasis and melanogenesis: which differences between psoriatic and healthy skin? |
| Autori: | Autore Email Di Costanzo, Luisa luisadicostanzo@virgilio.it |
| Data: | 31 Marzo 2014 |
| Numero di pagine: | 30 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Fisiopatologia clinica e medicina sperimentale |
| Ciclo di dottorato: | 26 |
| Coordinatore del Corso di dottorato: | nome email Marone, Gianni marone@unina.it |
| Tutor: | nome email Ayala, Fabio [non definito] |
| Data: | 31 Marzo 2014 |
| Numero di pagine: | 30 |
| Parole chiave: | Psoriasis, melanogenesis |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree |
| Depositato il: | 08 Apr 2014 11:15 |
| Ultima modifica: | 15 Lug 2015 01:01 |
| URI: | http://www.fedoa.unina.it/id/eprint/9865 |
Abstract
Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferative epidermis and mixed cutaneous lymphocytic infiltrate that occurs in genetically predisposed individuals. Many immune-derived cytokines, including interleukin (IL)-1, IL-6, IL-17, IL-19, IL-20, IL-22, tumour necrosis factor (TNF)-a and interferon (IFN)s, are over-expressed in psoriasis skin which may contribute to psoriatic skin inflammation and can also regulate keratinocyte proliferation. It has been demonstrated that keratinocytes synthesize and secrete many cytokines; some of these interact with many other skin cells, particularly with melanocytes. Melanocytes produce melanin by melanogenesis complex biochemical pathway. Keratinocytes, melanocytes communicate with each other by secreted factors and by cell-cell contacts. Particularly, keratinocytes control melanocyte growth and activity through a system of paracrine growth factors and cell adhesion molecules. In addition, several keratinocyte-derived cytokines known to inhibit human melanogenesis have been identified; these include transforming growth factor-β (TGF-β), INF-β, IL-1, IL-6, TNF-α. The possible immunological interaction between psoriasis and melanogenesis is particularly interesting for clinical and therapeutic implications. Aim of our study was to investigate possible differences in melanogenesis markers between psoriatic and healthy skin. In particular, we analyzed the possible involvement of Tyrosinase, MITF, and BMP-4. Our study evidenced a reduction of Tyrosinase, MITF and BMP-4 in psoriatic skin respect to healthy skin.
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