Di Costanzo, Luisa (2014) Psoriasis and melanogenesis: which differences between psoriatic and healthy skin? [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Psoriasis and melanogenesis: which differences between psoriatic and healthy skin?
Creators:
CreatorsEmail
Di Costanzo, Luisaluisadicostanzo@virgilio.it
Date: 31 March 2014
Number of Pages: 30
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Fisiopatologia clinica e medicina sperimentale
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nomeemail
Marone, Giannimarone@unina.it
Tutor:
nomeemail
Ayala, FabioUNSPECIFIED
Date: 31 March 2014
Number of Pages: 30
Uncontrolled Keywords: Psoriasis, melanogenesis
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree
Date Deposited: 08 Apr 2014 11:15
Last Modified: 15 Jul 2015 01:01
URI: http://www.fedoa.unina.it/id/eprint/9865

Abstract

Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferative epidermis and mixed cutaneous lymphocytic infiltrate that occurs in genetically predisposed individuals. Many immune-derived cytokines, including interleukin (IL)-1, IL-6, IL-17, IL-19, IL-20, IL-22, tumour necrosis factor (TNF)-a and interferon (IFN)s, are over-expressed in psoriasis skin which may contribute to psoriatic skin inflammation and can also regulate keratinocyte proliferation. It has been demonstrated that keratinocytes synthesize and secrete many cytokines; some of these interact with many other skin cells, particularly with melanocytes. Melanocytes produce melanin by melanogenesis complex biochemical pathway. Keratinocytes, melanocytes communicate with each other by secreted factors and by cell-cell contacts. Particularly, keratinocytes control melanocyte growth and activity through a system of paracrine growth factors and cell adhesion molecules. In addition, several keratinocyte-derived cytokines known to inhibit human melanogenesis have been identified; these include transforming growth factor-β (TGF-β), INF-β, IL-1, IL-6, TNF-α. The possible immunological interaction between psoriasis and melanogenesis is particularly interesting for clinical and therapeutic implications. Aim of our study was to investigate possible differences in melanogenesis markers between psoriatic and healthy skin. In particular, we analyzed the possible involvement of Tyrosinase, MITF, and BMP-4. Our study evidenced a reduction of Tyrosinase, MITF and BMP-4 in psoriatic skin respect to healthy skin.

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