Catanzano, Ovidio (2014) HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS |
| Autori: | Autore Email Catanzano, Ovidio ovidio.catanzano@unina.it |
| Data: | 31 Marzo 2014 |
| Numero di pagine: | 148 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Farmacia |
| Scuola di dottorato: | Scienze farmaceutiche |
| Dottorato: | Scienza del farmaco |
| Ciclo di dottorato: | 26 |
| Coordinatore del Corso di dottorato: | nome email D'Auria, Maria Valeria madauria@unina.it |
| Tutor: | nome email Calignano, Antonio [non definito] |
| Data: | 31 Marzo 2014 |
| Numero di pagine: | 148 |
| Parole chiave: | Wound Healing,Drug Delivery, Alginate, Nanoemulsion, Nanosilver |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/09 - Farmaceutico tecnologico applicativo |
| Aree tematiche (7° programma Quadro): | NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Nanoscienze e Nanotecnologie |
| Depositato il: | 07 Apr 2014 09:56 |
| Ultima modifica: | 15 Lug 2015 01:02 |
| URI: | http://www.fedoa.unina.it/id/eprint/9976 |
Abstract
Wound repair is a complex and coordinated process that involves the participation of all the principal molecular and biochemical processes involved in growth and cell differentiation. The in situ administration of bioactive molecules through drug delivery systems can result in enormous therapeutic benefits as it would increase the concentration of the active drugs in the site of interest in time, minimizing the systemic action. In case of both acute and chronic wounds, a local delivery permits a more rapid wound healing with reduced complications due to infection or other diseases. Based on these considerations, the purpose of this thesis is the development of innovative polymer-based delivery systems capable to exert a direct action on wound healing promoting a rapid recovery of tissue function. In the first three chapters alginate-based hydrogels useful for wound treatment in form of hydrated and spongy-like sheets, have been successfully developed. Using different gelation techniques, silver nanoparticles and tea tree oil nanoemulsions were loaded in the alginate hydrogel to obtain a bioactivatedl device with a direct action on wound healing process. Finally, hybrid synthetic hydrotalcite particles loaded with an anti-inflammatory drug were integrated in biodegradable fibers with the aim to achieve bioactive sutures.
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