Catanzano, Ovidio (2014) HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS. [Tesi di dottorato]

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS
Autori:
AutoreEmail
Catanzano, Ovidioovidio.catanzano@unina.it
Data: 31 Marzo 2014
Numero di pagine: 148
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Farmacia
Scuola di dottorato: Scienze farmaceutiche
Dottorato: Scienza del farmaco
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Calignano, Antonio[non definito]
Data: 31 Marzo 2014
Numero di pagine: 148
Parole chiave: Wound Healing,Drug Delivery, Alginate, Nanoemulsion, Nanosilver
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/09 - Farmaceutico tecnologico applicativo
Aree tematiche (7° programma Quadro): NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Nanoscienze e Nanotecnologie
Depositato il: 07 Apr 2014 09:56
Ultima modifica: 15 Lug 2015 01:02
URI: http://www.fedoa.unina.it/id/eprint/9976

Abstract

Wound repair is a complex and coordinated process that involves the participation of all the principal molecular and biochemical processes involved in growth and cell differentiation. The in situ administration of bioactive molecules through drug delivery systems can result in enormous therapeutic benefits as it would increase the concentration of the active drugs in the site of interest in time, minimizing the systemic action. In case of both acute and chronic wounds, a local delivery permits a more rapid wound healing with reduced complications due to infection or other diseases. Based on these considerations, the purpose of this thesis is the development of innovative polymer-based delivery systems capable to exert a direct action on wound healing promoting a rapid recovery of tissue function. In the first three chapters alginate-based hydrogels useful for wound treatment in form of hydrated and spongy-like sheets, have been successfully developed. Using different gelation techniques, silver nanoparticles and tea tree oil nanoemulsions were loaded in the alginate hydrogel to obtain a bioactivatedl device with a direct action on wound healing process. Finally, hybrid synthetic hydrotalcite particles loaded with an anti-inflammatory drug were integrated in biodegradable fibers with the aim to achieve bioactive sutures.

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