Catanzano, Ovidio (2014) HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS
Creators:
CreatorsEmail
Catanzano, Ovidioovidio.catanzano@unina.it
Date: 31 March 2014
Number of Pages: 148
Institution: Università degli Studi di Napoli Federico II
Department: Farmacia
Scuola di dottorato: Scienze farmaceutiche
Dottorato: Scienza del farmaco
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Calignano, AntonioUNSPECIFIED
Date: 31 March 2014
Number of Pages: 148
Uncontrolled Keywords: Wound Healing,Drug Delivery, Alginate, Nanoemulsion, Nanosilver
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/09 - Farmaceutico tecnologico applicativo
Aree tematiche (7° programma Quadro): NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Nanoscienze e Nanotecnologie
Date Deposited: 07 Apr 2014 09:56
Last Modified: 15 Jul 2015 01:02
URI: http://www.fedoa.unina.it/id/eprint/9976

Abstract

Wound repair is a complex and coordinated process that involves the participation of all the principal molecular and biochemical processes involved in growth and cell differentiation. The in situ administration of bioactive molecules through drug delivery systems can result in enormous therapeutic benefits as it would increase the concentration of the active drugs in the site of interest in time, minimizing the systemic action. In case of both acute and chronic wounds, a local delivery permits a more rapid wound healing with reduced complications due to infection or other diseases. Based on these considerations, the purpose of this thesis is the development of innovative polymer-based delivery systems capable to exert a direct action on wound healing promoting a rapid recovery of tissue function. In the first three chapters alginate-based hydrogels useful for wound treatment in form of hydrated and spongy-like sheets, have been successfully developed. Using different gelation techniques, silver nanoparticles and tea tree oil nanoemulsions were loaded in the alginate hydrogel to obtain a bioactivatedl device with a direct action on wound healing process. Finally, hybrid synthetic hydrotalcite particles loaded with an anti-inflammatory drug were integrated in biodegradable fibers with the aim to achieve bioactive sutures.

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