Micciarelli, Marco (2014) Model system approach to the study of UV induced DNA protein crosslink reactions. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Model system approach to the study of UV induced DNA protein crosslink reactions
Creators:
CreatorsEmail
Micciarelli, Marcomarco.micciarelli@na.infn.it
Date: 31 March 2014
Number of Pages: 153
Institution: Università degli Studi di Napoli Federico II
Department: Fisica
Scuola di dottorato: Scienze fisiche
Dottorato: Fisica fondamentale ed applicata
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Velotta, Raffaelervelotta@unina.it
Tutor:
nomeemail
Altucci, CarloUNSPECIFIED
Tavernelli, IvanoUNSPECIFIED
Date: 31 March 2014
Number of Pages: 153
Uncontrolled Keywords: crosslink, photoreactions, molecular dynamics
Settori scientifico-disciplinari del MIUR: Area 02 - Scienze fisiche > FIS/03 - Fisica della materia
Area 02 - Scienze fisiche > FIS/07 - Fisica applicata (a beni culturali, ambientali, biologia e medicina)
Aree tematiche (7° programma Quadro): SALUTE e TUTELA DEL CONSUMATORE > Biotecnologie, strumenti e tecnologie generiche per la salute umana
NANOSCIENZE, NANOTECNOLOGIE, MATERIALE E PRODUZIONE > Materiali
Date Deposited: 08 Apr 2014 10:20
Last Modified: 28 Jan 2015 09:35
URI: http://www.fedoa.unina.it/id/eprint/9983

Abstract

In this thesis the photoreaction leading from 5-benzyluracil (5BU) to the formation of a cyclized compound, the 5,6BU is studied using several ab initio molecular dynamics computational methods. The reaction is studied as model for the UV induced DNA protein crosslink reaction. The exploration of the reaction mechanism provides new insights in the construction of an efficient methodology to stabilize with UV puled lasers the transient interactions between DNA and close lying proteins in a biological environment.

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