Celentano, Luigi and Laccetti, Paolo and Marotta, Marcello and Mettivier, Giovanni and Quarto, Maria and Riccio, Patrizia and Roberti, Giuseppe and Russo, Paolo (2007) Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395. [Pubblicazione in rivista scientifica]

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Tipologia del documento:	Pubblicazione in rivista scientifica
Lingua:	English
Titolo:	Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395.
Autori:	Autore Email Celentano, Luigi [non definito] Laccetti, Paolo [non definito] Marotta, Marcello [non definito] Mettivier, Giovanni [non definito] Quarto, Maria [non definito] Riccio, Patrizia [non definito] Roberti, Giuseppe [non definito] Russo, Paolo [non definito]
Autore/i:	M. Autiero, L. Celentano, R. Cozzolino, P. Laccetti, M. Marotta, G. Mettivier, M. Quarto, P. Riccio, G. Roberti, P. Russo
Data:	2007
Numero di pagine:	3
Dipartimento:	Scienze fisiche
Numero identificativo:	10.1016/j.nima.2006.10.117
Titolo del periodico:	NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT
Data:	2007
Volume:	571
Intervallo di pagine:	pp. 392-395
Numero di pagine:	3
Numero identificativo:	10.1016/j.nima.2006.10.117
Depositato il:	20 Ott 2010 08:34
Ultima modifica:	30 Apr 2014 19:42
URI:	http://www.fedoa.unina.it/id/eprint/6844

Abstract

We investigated the capability of fluorescence reflectance imaging (FRI) for the early detection of surface tumors in mice. We used a hematoporphyrin (HP) compound (HP dichlorohydrate) as a red fluorescent marker and a low noise, high sensitivity, digital CCD camera for fluorescence imaging. In this preliminary study, highly malignant anaplastic human thyroid carcinoma cells were implanted subcutaneously in one mouse and their growth was monitored daily for 5 days by FRI. The selective HP uptake by the tumor tissues was successfully observed: we observed the fluorescence of tumor only 3 days after cancer cells injection, i.e. when the tumor mass was neither visible (to the naked eye) or palpable. These measurements indicate that FRI is a suitable technique to detect minute subcutaneous tumor masses. This FRI system will be coupled to a radionuclide imaging system based on a CdTe detector for in vivo multimodal imaging in mice.

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