Sacchettino, Luigi (2024) Altered microbiome and metabolome profiling in fearful companion dogs:an exploratory study. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Altered microbiome and metabolome profiling in fearful companion dogs:an exploratory study |
| Autori: | Autore Email Sacchettino, Luigi luigi.sacchettino@unina.it |
| Data: | 2024 |
| Numero di pagine: | 59 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Veterinaria e Produzioni Animali |
| Dottorato: | Scienze veterinarie |
| Ciclo di dottorato: | 37 |
| Coordinatore del Corso di dottorato: | nome email De Girolamo, Paolo degirola@unina.it |
| Tutor: | nome email d'Angelo, Danila [non definito] |
| Data: | 2024 |
| Numero di pagine: | 59 |
| Parole chiave: | animal; behavioral disorders; anxiety; microbiota; gut-brain axis; phosphatidylcolines |
| Settori scientifico-disciplinari del MIUR: | Area 07 - Scienze agrarie e veterinarie > VET/02 - Fisiologia veterinaria |
| Informazioni aggiuntive: | Appartenente al 37° Ciclo in Scienze Veterinarie (indicato 36esimo ciclo poichè il sistema non permetteva di flaggare 37esimo). |
| Depositato il: | 30 Gen 2025 06:24 |
| Ultima modifica: | 02 Set 2026 08:06 |
| URI: | https://www.fedoa.unina.it/id/eprint/16328 |
Abstract
Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. They can bring about signs of stress or fear in dogs, either in unique situations or in multiple settings, apart from the presence of scaring stimuli (human, animal, place, scent, auditory stimuli, object). Accordingly, alongside with genetic susceptibility, generalized fear can be triggered by environmental factors, traumatic experiences, and medical conditions. Behavioral therapy, context-suited management and neurochemical manipulation, through nutrition, supplements, medicines, and pheromones, are the mainstays of the currently accessible treatments. Recent and growing evidence in humans and animals highlight the importance of the gut-brain axis in the modulation of the brain physiology and behavior. Therefore, during my PhD programme, taking advantage of high-throughput approaches, we sought to investigate the impact of the generalized fear upon microbiota, metabolome and lipidomic signatures in family dogs. Microbiota analysis from the stool of the dogs diagnosed with fear showed a differential abundance of taxa belonging to Proteobacteria and Firmicutes Phyla, when compared to the healthy control group. In addition, serum metabolome profiling documented alterations of molecules associated with GABA and glutamate neurotransmission, as well as bile acids metabolism, in the case group. Finally, the patients showed altered levels of phosphatidylcholines, which are regarded as key building block of the cell membranes and relevant players of the brain function as well. Overall, our preliminary study highlighted an intriguing role for the microbiota-metabolome-lipidome network in the generalized fear, thus shedding light on a better understanding about the pathophysiology of mood-related dysfunctions affecting companion animals and paving the way for more effective therapeutical approaches.
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