Calvanese, Chiara Maria (2025) Genomic characterization of Lactic Acid Bacteria strains for novel pro- and post-biotics development. [Tesi di dottorato]

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Abstract

In this study, we leverage a multiomics approach to select and develop novel pro- or postbiotic products with beneficial effects on human health. In particular, Chapter 2 provides an introduction to the emerging and promising fields of pro- and postbiotics; in Chapter 3 starting from a genomic screening of vaginal isolates from 25 fertile and menopausal women and from the comparative genomics of these strains with other isolates of the same species, we identified a complementary role of different vaginal species in key activities that may be linked to women's health, highlighting the promising avenue for the development of a multispecies probiotic product; Chapter 4 demonstrate how probiogenomic approach can facilitate the selection and design of psychobiotics for clinical use, deepening the understanding of how microbes can influence the nervous system and host behavior; Finally, in Chapter 5 we developed psychobiotic consortia of lactic acid bacteria and used them for the fermentation of plant-based matrices. A plant-based yogurt-like (YL) product was developed and finally tested in an m-SHIME® model to evaluate the possible role in microbiome modulation and in situ production of neuroactive compounds.

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