Quaglia, Filomena
(2014)
Metabolic syndrome (MetS) and pregnancy.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Metabolic syndrome (MetS) and pregnancy |
| Autori: |
| Autore | Email |
|---|
| Quaglia, Filomena | filomenaquaglia@libero.it |
|
| Data: |
31 Marzo 2014 |
| Numero di pagine: |
103 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Scienze Mediche Traslazionali |
| Scuola di dottorato: |
Medicina clinica e sperimentale |
| Dottorato: |
Riproduzione, sviluppo ed accrescimento dell'uomo |
| Ciclo di dottorato: |
25 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Pignata, Claudio | claudio.pignata@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Martinelli, Pasquale | [non definito] |
|
| Data: |
31 Marzo 2014 |
| Numero di pagine: |
103 |
| Parole chiave: |
pregnancy; metabolic syndrome; preclampsia; obesity; epigenetic |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/09 - Medicina interna
Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia |
[error in script]
[error in script]
| Depositato il: |
09 Apr 2014 08:01 |
| Ultima modifica: |
23 Feb 2015 15:30 |
| URI: |
http://www.fedoa.unina.it/id/eprint/10030 |
Abstract
The increasing prevalence of overweight and obesity among women of childbearing age, is a growing public health problem in the world.(1) The nutritional status represents one of the most important factor that determines individual wellbeing, in particolar maternal- fetal health, during and after pregnancy. (2) Obese women compared to normal-weight have a higher risk of having reduced sensitivity to insulin. The combination of obesity and reduced insulin sensitivity, increases the long-term risk of developing the metabolic syndrome. The number of pre-obese women (25> BMI <30) and obese (BMI> 30) who become pregnant is definitely on the rise (3) . The state of nutrition is one of the most important determinant the welfare of the individual, especially of the maternal-fetal development; often even the flexibility of the metabolic response of the pregnant woman is able to correct for the imbalance and nutritional pregravid / or metabolic alterations induced by lifestyle; therefore, negative events can be correlated with being overweight.. For metabolic disorders evolved during a normal pregnancy, particularly showing a 60% reduction in insulin sensitivity, these women have a higher risk of metabolic disregulation and complications and adverse fetal outcomes, including preeclampsia, gestational diabetes, increased incidence of cesarean section, macrosomia and fetal death (4). The metabolic syndrome is a combination of cardiometabolic risk determinants such as obesity, insulin resistance, glucose intolerance, dyslipidemia, non-alcoholic fatty liver, hypertension. Pregnancy in these women may be seen as a metabolic stress test for the future risk of metabolic syndrome.
The prevalence of the metabolic syndrome is increasing worldwide as a result of obesity, with a significant impact on the incidence of cardiovascular disease and type 2 diabetes.
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