Quaglia, Filomena (2014) Metabolic syndrome (MetS) and pregnancy. [Tesi di dottorato]
Preview |
Text
QUAGLIA_FILOMENA_25.pdf Download (8MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Metabolic syndrome (MetS) and pregnancy |
| Creators: | Creators Email Quaglia, Filomena filomenaquaglia@libero.it |
| Date: | 31 March 2014 |
| Number of Pages: | 103 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Scienze Mediche Traslazionali |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Riproduzione, sviluppo ed accrescimento dell'uomo |
| Ciclo di dottorato: | 25 |
| Coordinatore del Corso di dottorato: | nome email Pignata, Claudio claudio.pignata@unina.it |
| Tutor: | nome email Martinelli, Pasquale UNSPECIFIED |
| Date: | 31 March 2014 |
| Number of Pages: | 103 |
| Keywords: | pregnancy; metabolic syndrome; preclampsia; obesity; epigenetic |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/09 - Medicina interna Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia |
| Date Deposited: | 09 Apr 2014 08:01 |
| Last Modified: | 23 Feb 2015 15:30 |
| URI: | http://www.fedoa.unina.it/id/eprint/10030 |
Collection description
The increasing prevalence of overweight and obesity among women of childbearing age, is a growing public health problem in the world.(1) The nutritional status represents one of the most important factor that determines individual wellbeing, in particolar maternal- fetal health, during and after pregnancy. (2) Obese women compared to normal-weight have a higher risk of having reduced sensitivity to insulin. The combination of obesity and reduced insulin sensitivity, increases the long-term risk of developing the metabolic syndrome. The number of pre-obese women (25> BMI <30) and obese (BMI> 30) who become pregnant is definitely on the rise (3) . The state of nutrition is one of the most important determinant the welfare of the individual, especially of the maternal-fetal development; often even the flexibility of the metabolic response of the pregnant woman is able to correct for the imbalance and nutritional pregravid / or metabolic alterations induced by lifestyle; therefore, negative events can be correlated with being overweight.. For metabolic disorders evolved during a normal pregnancy, particularly showing a 60% reduction in insulin sensitivity, these women have a higher risk of metabolic disregulation and complications and adverse fetal outcomes, including preeclampsia, gestational diabetes, increased incidence of cesarean section, macrosomia and fetal death (4). The metabolic syndrome is a combination of cardiometabolic risk determinants such as obesity, insulin resistance, glucose intolerance, dyslipidemia, non-alcoholic fatty liver, hypertension. Pregnancy in these women may be seen as a metabolic stress test for the future risk of metabolic syndrome. The prevalence of the metabolic syndrome is increasing worldwide as a result of obesity, with a significant impact on the incidence of cardiovascular disease and type 2 diabetes.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
