Palmieri, Teresa (2017) Perinatal preterm brain injury. Risk assessment, antenatal surveillance and managing. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: Perinatal preterm brain injury. Risk assessment, antenatal surveillance and managing
Date: 2 April 2017
Number of Pages: 82
Institution: Università degli Studi di Napoli Federico II
Department: Neuroscienze e Scienze Riproduttive ed Odontostomatologiche
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Neuroscienze
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
Locci, MariavittoriaUNSPECIFIED
Date: 2 April 2017
Number of Pages: 82
Keywords: brain injury; IUGR; Preterm Delivery
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/26 - Neurologia
Area 06 - Scienze mediche > MED/36 - Diagnostica per immagini e radioterapia
Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica
Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia
Date Deposited: 20 Apr 2017 11:08
Last Modified: 13 Mar 2018 11:36
DOI: 10.6093/UNINA/FEDOA/11484

Collection description

This work reports the results of two different lines of research: 1. On the employment of ultrasound in the management of fetuses with intra-uterine growth restriction (IUGR); 2. On management of preterm birth for prevention of neurological impairment in high-risk pregnancies and low risk pregnancies. Pre-natal flow data and post-natal neurological outcome in IUGR fetuses have been evaluated. Doppler ultrasound in obstetrics has allowed the detection of the early signs of fetal demise, involving the management of pregnancies at risk of fetal hypoxia. The second line of research focuses on the need to identify strategies to predict preterm birth in asymptomatic low-risk women as well as in those presenting with threatened preterm labor (symptomatic high risk women) and underlines the importance to prevent brain injury and long-term neurological sequelae related to preterm deliveries. Neurological insults result in significant immediate and longterm physical, emotional, and financial costs. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to improve neurological outcomes in infants delivered preterm but also primarily to decrease preterm delivery.


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