Napolitano, Raffaele (2017) Fetal brain growth and development. [Tesi di dottorato]

R. Napolitano - Tesi di Dottorato in Neuroscienze - 2017.4.3.pdf

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Item Type: Tesi di dottorato
Lingua: English
Title: Fetal brain growth and development
Date: 2017
Number of Pages: 208
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Clinica e Chirurgia
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
Annunziato, LucioUNSPECIFIED
Martinelli, PasqualeUNSPECIFIED
Date: 2017
Number of Pages: 208
Uncontrolled Keywords: fetal brain structure, ultrasound, charts, standards.
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia
Date Deposited: 20 Apr 2017 08:02
Last Modified: 13 Mar 2018 11:31
DOI: 10.6093/UNINA/FEDOA/11490


The main aim of this project was to create international standards for fetal brain structures size using ultrasound measurements. Fetal brain growth and development is routinely studied using prenatal ultrasound. Ultrasound is used mainly in antenatal care to diagnose fetal abnormalities but it is also essential in evaluating fetal growth and central nervous system development. Fetal growth restriction can affect neurodevelopment and therefore a population at low risk of growth problems should be selected to create such standards. Women recruited in the fetal study of the INTERGROWTH-21st Project represent the ideal candidate. This study uses a ‘prescriptive’ other than a ‘descriptive’ design to study the fetal growth, i.e. only children from populations with minimal environmental constraints on growth were included. Previous studies on fetal growth are associated with high risk of bias when a descriptive approach was used. A systematic review of the literature has been performed to identify all the studies aimed to create brain structures charts. There is substantial heterogeneity in the methodology used in previous studies aimed to create brain structures charts. As a conclusion international standards are required. International standards for six fetal brain structures size measured by antenatal ultrasound have been created with the highest quality methodology and good results of the model fitted. Those standards provide guidelines for ultrasound evaluation of the fetal brain and further understanding into the fetal brain development process in babies at low risk of abnormal neurological outcome.


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