Chiariello, Andrea Maria (2017) Polymer Physics and structural organization of chromosomes in mammalian genomes. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Polymer Physics and structural organization of chromosomes in mammalian genomes |
| Creators: | Creators Email Chiariello, Andrea Maria chiariello@na.infn.it |
| Date: | 10 April 2017 |
| Number of Pages: | 107 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Fisica |
| Dottorato: | Fisica |
| Ciclo di dottorato: | 29 |
| Coordinatore del Corso di dottorato: | nome email Capozziello, Salvatore UNSPECIFIED |
| Tutor: | nome email Mario Nicodemi, MN UNSPECIFIED |
| Date: | 10 April 2017 |
| Number of Pages: | 107 |
| Keywords: | Polymer physics, computer simulations, molecular biology, chromatin. |
| Settori scientifico-disciplinari del MIUR: | Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici |
| Date Deposited: | 03 May 2017 15:11 |
| Last Modified: | 08 Mar 2018 10:57 |
| URI: | http://www.fedoa.unina.it/id/eprint/11538 |
| DOI: | 10.6093/UNINA/FEDOA/11538 |
Collection description
Chromosomes in mammalian cell nucleus have a very complex spatial organization, linked to important functional purposes. In this PhD thesis, we show that the organization is hierarchical from very low length scales up to entire chromosomes scale. Then, we use polymer physics to describe general aspects of chromosome architecture. Finally, we presents polymer physics based computational methods to accurately reconstruct the 3D structure of real loci of the genome.
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