Chiariello, Andrea Maria (2017) Polymer Physics and structural organization of chromosomes in mammalian genomes. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Polymer Physics and structural organization of chromosomes in mammalian genomes
Creators:
CreatorsEmail
Chiariello, Andrea Mariachiariello@na.infn.it
Date: 10 April 2017
Number of Pages: 107
Institution: Università degli Studi di Napoli Federico II
Department: Fisica
Dottorato: Fisica
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
nomeemail
Capozziello, SalvatoreUNSPECIFIED
Tutor:
nomeemail
Mario Nicodemi, MNUNSPECIFIED
Date: 10 April 2017
Number of Pages: 107
Uncontrolled Keywords: Polymer physics, computer simulations, molecular biology, chromatin.
Settori scientifico-disciplinari del MIUR: Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici
Date Deposited: 03 May 2017 15:11
Last Modified: 08 Mar 2018 10:57
URI: http://www.fedoa.unina.it/id/eprint/11538
DOI: 10.6093/UNINA/FEDOA/11538

Abstract

Chromosomes in mammalian cell nucleus have a very complex spatial organization, linked to important functional purposes. In this PhD thesis, we show that the organization is hierarchical from very low length scales up to entire chromosomes scale. Then, we use polymer physics to describe general aspects of chromosome architecture. Finally, we presents polymer physics based computational methods to accurately reconstruct the 3D structure of real loci of the genome.

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