Borrelli, Rosaria
(2017)
Neuroendocrine axis and reproduction.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Neuroendocrine axis and reproduction |
| Autori: |
| Autore | Email |
|---|
| Borrelli, Rosaria | rosaria.borrelli@yahoo.it |
|
| Data: |
7 Aprile 2017 |
| Numero di pagine: |
114 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Neuroscienze e Scienze Riproduttive ed Odontostomatologiche |
| Dottorato: |
Neuroscienze |
| Ciclo di dottorato: |
29 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Annunziato, Lucio | lannunzi@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Alviggi, Carlo | [non definito] |
|
| Data: |
7 Aprile 2017 |
| Numero di pagine: |
114 |
| Parole chiave: |
gonadal axis; endogenous and exogeneous variables; PCOS; endometriosis |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/13 - Endocrinologia
Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia |
[error in script]
[error in script]
| Depositato il: |
20 Apr 2017 08:02 |
| Ultima modifica: |
13 Mar 2018 11:28 |
| URI: |
http://www.fedoa.unina.it/id/eprint/11574 |
| DOI: |
10.6093/UNINA/FEDOA/11574 |
Abstract
This PhD thesis is based on the conduct of two lines of research focused on alterations in the
hypothalamic-pituitary-gonad axis functioning. The two most common disorders of ovarian
function, micropolycystic ovary syndrome (PCOS) and endometriosis, have been identified as
models to assess the impact, on the axis, of endogenous and environmental variables, respectively.
The first line of research has been focused on the hypothesis that the two main forms of clinical
expression of PCOS, the strictly linked to hyperandrogenism and that one associated to insulin
resistance, represent distinct disease entities and are, consequently, supported by different
pathogenetic mechanisms. This hypothesis finds its origin on the fact that these two forms
determine distinguishable endocrine and metabolic profiles. Nevertheless, there are no studies
5
investigating whether the PCOS phenotype differently alters the morphology gonads . On this basis,
a clinical observational study has been conducted in PCOS women, aimed at evaluating the
relationship between ultrasound pictures of polycystic ovaries and the endocrine-metabolic state of
patients.
The second line of research stems from the hypothesis of a possible role of environmental pollutants
on another of the most common reproductive age pathologies: endometriosis. The disease affects 6-
10% of women and its exact etiology remains unknown. The possible role of toxic agents was
proposed back in 1993 by Rier and collaborators and, since then, the interest in the impact on it of
contaminants has been high. A systematic review of literature through electronic database was
conducted without time restriction in order to analyze the relation between endometriosis and the
most common environmental pollutants.
The PhD thesis is organized in three chapters. The first two are aimed to report results from the
main lines of research. A third chapter regards a parallel research experience that the PhD student
started in the last year, during her fellowship at the University “Mangiagalli” of Milan (Italy). Each
chapter is further divided in a first part concerning what‟s is known for any single topic and a
second one dedicated to related studies done during the PhD.
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