De Sarno, Franca (2018) Entrapping Contrast Agent in Nanovescicles. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Entrapping Contrast Agent in Nanovescicles |
| Autori: | Autore Email De Sarno, Franca francesca.desarno@gmail.com |
| Data: | 10 Settembre 2018 |
| Numero di pagine: | 158 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | dep08 |
| Dottorato: | phd038 |
| Ciclo di dottorato: | 30 |
| Coordinatore del Corso di dottorato: | nome email Mensitieri, Giuseppe mensitie@unina.it |
| Tutor: | nome email Netti, Paolo Antonio [non definito] Torino, Enza [non definito] |
| Data: | 10 Settembre 2018 |
| Numero di pagine: | 158 |
| Parole chiave: | MRI; Contrast Agent; Hydrodenticity; Biopolymer |
| Settori scientifico-disciplinari del MIUR: | Area 09 - Ingegneria industriale e dell'informazione > ING-IND/34 - Bioingegneria industriale |
| Depositato il: | 11 Set 2018 09:07 |
| Ultima modifica: | 18 Apr 2019 13:28 |
| URI: | http://www.fedoa.unina.it/id/eprint/12315 |
Abstract
Cancer and cardiovascular diseases are silent killers which cause million deaths worldwide every year and this number is expected to triple by 2035. Current diagnostic techniques cannot easily, safely, and effectively detect these human body lesions in the early stage, nor can they characterize the lesion features. In this context, the biological application of nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of pathologies. Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, understanding the MRI enhancement mechanism remains a challenge. Here, in order to develop a safe and more efficient MRI CA for imaging applications, the basic principles ruling biopolymer-CAs interactions are investigated to better understand their influence on the relaxometric properties of the CA by adopting a multidisciplinary experimental approach. In addition, the effect of the hydration of the hydrogel structure on the relaxometric properties, called Hydrodenticity, is used to develop Gadolinium-based polymer nanovectors with improved MRI relaxation time. The experimental results indicate that the entrapment of metal chelates in hydrogel nanostructures offers a versatile platform for developing different high performing CAs for diseases diagnosis.
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