De Sarno, Franca (2018) Entrapping Contrast Agent in Nanovescicles. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Entrapping Contrast Agent in Nanovescicles
Creators:
CreatorsEmail
De Sarno, Francafrancesca.desarno@gmail.com
Date: 10 September 2018
Number of Pages: 158
Institution: Università degli Studi di Napoli Federico II
Department: dep08
Dottorato: phd038
Ciclo di dottorato: 30
Coordinatore del Corso di dottorato:
nomeemail
Mensitieri, Giuseppemensitie@unina.it
Tutor:
nomeemail
Netti, Paolo AntonioUNSPECIFIED
Torino, EnzaUNSPECIFIED
Date: 10 September 2018
Number of Pages: 158
Uncontrolled Keywords: MRI; Contrast Agent; Hydrodenticity; Biopolymer
Settori scientifico-disciplinari del MIUR: Area 09 - Ingegneria industriale e dell'informazione > ING-IND/34 - Bioingegneria industriale
Date Deposited: 11 Sep 2018 09:07
Last Modified: 18 Apr 2019 13:28
URI: http://www.fedoa.unina.it/id/eprint/12315

Abstract

Cancer and cardiovascular diseases are silent killers which cause million deaths worldwide every year and this number is expected to triple by 2035. Current diagnostic techniques cannot easily, safely, and effectively detect these human body lesions in the early stage, nor can they characterize the lesion features. In this context, the biological application of nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of pathologies. Recently, rational design of a new class of contrast agents (CAs), based on biopolymers (hydrogels), have received considerable attention in Magnetic Resonance Imaging (MRI) diagnostic field. Several strategies have been adopted to improve relaxivity without chemical modification of the commercial CAs, however, understanding the MRI enhancement mechanism remains a challenge. Here, in order to develop a safe and more efficient MRI CA for imaging applications, the basic principles ruling biopolymer-CAs interactions are investigated to better understand their influence on the relaxometric properties of the CA by adopting a multidisciplinary experimental approach. In addition, the effect of the hydration of the hydrogel structure on the relaxometric properties, called Hydrodenticity, is used to develop Gadolinium-based polymer nanovectors with improved MRI relaxation time. The experimental results indicate that the   entrapment of metal chelates in hydrogel nanostructures offers a versatile platform for developing different high performing CAs for diseases diagnosis.

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