Morello, Andrea (2020) Vitamin D inhibits Tissue Factor and CAMs expression in Oxidized Low-Density Lipoproteins-treated human endothelial cells by modulating NF-κB pathway. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Vitamin D inhibits Tissue Factor and CAMs expression in Oxidized Low-Density Lipoproteins-treated human endothelial cells by modulating NF-κB pathway
Creators:
CreatorsEmail
Morello, Andreadr_andrea.morello@hotmail.it
Date: 3 March 2020
Number of Pages: 54
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Biomediche Avanzate
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
nomeemail
Beguinot, Francescobeguino@unina.it
Tutor:
nomeemail
Cirillo, PlinioUNSPECIFIED
Date: 3 March 2020
Number of Pages: 54
Keywords: vitamin_D;cardiovascular_disease;athero-thrombosis;adhesion_molecules_(CAMs);Tissue_Factor_(TF);atherothrombotic_pathophysiology;endothelial_cells_(HUVEC);ox-LDL;NF-kB;
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/12 - Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/04 - Patologia generale
Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare
Date Deposited: 26 Mar 2020 08:49
Last Modified: 17 Nov 2021 10:27
URI: http://www.fedoa.unina.it/id/eprint/13002

Collection description

Several epidemiologic studies have clearly demonstrated the correlation existing between vitamin D (VitD) deficiency and increased risk of developing cardiovascular disease, suggesting that it might have a hypothetical protective role in this clinical setting. To date, although many experimental studies have investigated the molecular mechanisms by which VitD might exert these effects, its role in protecting against athero-thrombosis is still partially unknown. This study has investigated whether VitD might exert anti athero-thombotic effects by preventing expression of adhesion molecules (CAMs) and Tissue Factor (TF), that are actively involved in atherothrombotic pathophysiology, in endothelial cells (HUVEC) stimulated with ox-LDL. Moreover, we have investigated whether VitD effects might be due to the NF-kB modulation.

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