Morello, Andrea (2020) Vitamin D inhibits Tissue Factor and CAMs expression in Oxidized Low-Density Lipoproteins-treated human endothelial cells by modulating NF-κB pathway. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Vitamin D inhibits Tissue Factor and CAMs expression in Oxidized Low-Density Lipoproteins-treated human endothelial cells by modulating NF-κB pathway |
| Autori: | Autore Email Morello, Andrea dr_andrea.morello@hotmail.it |
| Data: | 3 Marzo 2020 |
| Numero di pagine: | 54 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 32 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email Cirillo, Plinio [non definito] |
| Data: | 3 Marzo 2020 |
| Numero di pagine: | 54 |
| Parole chiave: | vitamin_D;cardiovascular_disease;athero-thrombosis;adhesion_molecules_(CAMs);Tissue_Factor_(TF);atherothrombotic_pathophysiology;endothelial_cells_(HUVEC);ox-LDL;NF-kB; |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/12 - Biochimica clinica e biologia molecolare clinica Area 06 - Scienze mediche > MED/04 - Patologia generale Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare |
| Depositato il: | 26 Mar 2020 08:49 |
| Ultima modifica: | 17 Nov 2021 10:27 |
| URI: | http://www.fedoa.unina.it/id/eprint/13002 |
Abstract
Several epidemiologic studies have clearly demonstrated the correlation existing between vitamin D (VitD) deficiency and increased risk of developing cardiovascular disease, suggesting that it might have a hypothetical protective role in this clinical setting. To date, although many experimental studies have investigated the molecular mechanisms by which VitD might exert these effects, its role in protecting against athero-thrombosis is still partially unknown. This study has investigated whether VitD might exert anti athero-thombotic effects by preventing expression of adhesion molecules (CAMs) and Tissue Factor (TF), that are actively involved in atherothrombotic pathophysiology, in endothelial cells (HUVEC) stimulated with ox-LDL. Moreover, we have investigated whether VitD effects might be due to the NF-kB modulation.
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