Sirico, Angelo (2021) Neurotrophins expression in HIV positive women with squamous cervical cancer. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: Neurotrophins expression in HIV positive women with squamous cervical cancer
Date: 11 October 2021
Number of Pages: 64
Institution: Università degli Studi di Napoli Federico II
Department: Neuroscienze e Scienze Riproduttive ed Odontostomatologiche
Dottorato: Neuroscienze
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
Maruotti, Giuseppe MariaUNSPECIFIED
Date: 11 October 2021
Number of Pages: 64
Keywords: neurotrophins; neuroscience; HIV infection; HPV; cervical cancer
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/40 - Ginecologia e ostetricia
Date Deposited: 12 Oct 2021 14:23
Last Modified: 07 Jun 2023 11:16

Collection description

Neurotrophins are a family of proteins that induce the survival, development, and function of neurons. Due to the anterograde trasport, neurotrophins, in particular BDNF, are also expressed in human viscera, including the squamous epithelium of the portio, where BDNF has been demonstrated to promote keratinocyte proliferation via trkB. Cervical cancer cases are triggered by persistent infection of the uterine cervix by HPV HR genotypes, particularly HPV-16 and HPV-18. HIV-related immunodeficiency has complex effects on female genital HPV, which include increased risks of infection, multiple types, persistence, reactivation and the risk to develop pre-invasive and invasive disease. Women with HIV infection are more likely to develop pre-neoplastic and neoplastic cervical lesions caused by HPV when compared to seronegative women. It has been described that BDNF and trkB expression are significantly higher in cervical cancer tissues than in normal tissues and that their presence is higher in advanced stages of this neoplasm. Furthermore, HIV protein gp120 has been shown to upregulate BDNF expression. We hypothesize that neurotrophins, in HIV infected women, play a crucial role in the enhancement and in the accelerated progression of cervical pre-invasive and invasive lesions. Therefore, the aim of this study is to evaluate the expression of neurotrophins NGF and BDNF in specimens from pre-invasive or invasive cervical cancer lesions according to the HIV status of the patients.


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