Annunziata, Giuseppe (2021) Taurisolo®, a novel nutraceutical formulation based on grape pomace polyphenols, as a tool for the management of oxidative stress- and atherosclerosis-related diseases. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Taurisolo®, a novel nutraceutical formulation based on grape pomace polyphenols, as a tool for the management of oxidative stress- and atherosclerosis-related diseases
Creators:
CreatorsEmail
Annunziata, Giuseppegiuseppe.annunziata@unina.it
Date: 6 July 2021
Number of Pages: 221
Institution: Università degli Studi di Napoli Federico II
Department: Farmacia
Dottorato: Scienza del farmaco
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Tenore, Gian CarloUNSPECIFIED
Date: 6 July 2021
Number of Pages: 221
Keywords: polyphenols; nutraceutical; oxidative stress; atherosclerosis
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/10 - Chimica degli alimenti
Date Deposited: 20 Jul 2021 14:36
Last Modified: 07 Jun 2023 10:39
URI: http://www.fedoa.unina.it/id/eprint/13738

Collection description

The present PhD thesis summarises evidence from all the studies performed during the three-year PhD Course in Pharmaceutical Science, at the NutraPharmaLabs of the Department of Pharmacy, University of Naples Federico II, having as mail goal the evaluation of the nutraceutical potential of Taurisolo®, a novel nutraceutical formulation based on grape pomace polyphenolic extract. In particular, the present PhD project has been conducted in cooperation with both industrial (MBMed Company, Turin, Italy) and foreign University (University of Balearic Islands, Palma del Mallorca, Spain) partners. The entire project was planned with a dual view:  design and formulate a novel nutraceutical product starting from re-use of agri-food by-products, following all the steps required by the nutraceutical industry, including preventive characterisation of the chemical profile, evaluation of bioaccessibility and bioavailability of bioactive compounds, optimisation of the productive processes and their translation in large-scale, marketing techniques  evaluation of the biological activities, following a pharmacological approach including pre-clinical and clinical studies. More specifically, results herein presented refer to all the studies performed in our Labs and in collaboration with other Departments and Research Institutes. They include in vitro studies, animal-based studies and randomised clinical trials conducted on both healthy and pathological subjects. Further studies are still ongoing with the aim to clarify the main putative mechanisms of action for the cardioprotective role played by Taurisolo® or to provide novel insight regarding the observed clinical results. In summary, data so far collected allow concluding that Taurisolo® is a useful and valid polyphenol-based formulation with promising nutraceutical properties in reduction of risk factors related to both development and progression of cardiovascular diseases, in particular atherosclerosis.

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