Fattorusso, Valentina (2021) T1D progression is associated with loss of CD3+CD56+regulatory cells. [Tesi di dottorato]

Preview

Text Fattorusso_Valentina_33.pdf Download (3MB) | Preview

[error in script] [error in script]

Item Type:	Tesi di dottorato
Lingua:	English
Title:	T1D progression is associated with loss of CD3+CD56+regulatory cells
Creators:	Creators Email Fattorusso, Valentina vfattorusso1@gmail.com
Date:	11 April 2021
Number of Pages:	45
Institution:	Università degli Studi di Napoli Federico II
Department:	Scienze Mediche Traslazionali
Dottorato:	Medicina clinica e sperimentale
Ciclo di dottorato:	33
Coordinatore del Corso di dottorato:	nome email Beguinot, Francesco beguino@unina.it
Tutor:	nome email Franzese, Adriana UNSPECIFIED
Date:	11 April 2021
Number of Pages:	45
Uncontrolled Keywords:	T1D, regulatory cells, c-peptide
Settori scientifico-disciplinari del MIUR:	Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica
Date Deposited:	20 Apr 2021 07:41
Last Modified:	07 Jun 2023 13:20
URI:	http://www.fedoa.unina.it/id/eprint/13898

Abstract

Peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56, is reduced in subjects with new-onset type 1 diabetes (T1D). In three independent T1D cohorts, we find that low frequency of circulating TR3-56 cells is associated with reduced β-cell function and with the presence of diabetic ketoacidosis. We demonstrate that TR3-56 cells can suppress CD8+ T cell functions in vitro by reducing levels of intracellular reactive oxygen species. The suppressive function, phenotype and transcriptional signature of TR3-56 cells are also altered in T1D children. Together, our findings indicate that TR3-56 cells constitute a regulatory cell population that controls CD8+ effector functions, whose peripheral frequency may represent a traceable biomarker for monitoring immunological self-tolerance in T1D.

Downloads

Actions (login required)

View Item