Fattorusso, Valentina (2021) T1D progression is associated with loss of CD3+CD56+regulatory cells. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: T1D progression is associated with loss of CD3+CD56+regulatory cells
Creators:
CreatorsEmail
Fattorusso, Valentinavfattorusso1@gmail.com
Date: 11 April 2021
Number of Pages: 45
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
nomeemail
Beguinot, Francescobeguino@unina.it
Tutor:
nomeemail
Franzese, AdrianaUNSPECIFIED
Date: 11 April 2021
Number of Pages: 45
Keywords: T1D, regulatory cells, c-peptide
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica
Date Deposited: 20 Apr 2021 07:41
Last Modified: 07 Jun 2023 13:20
URI: http://www.fedoa.unina.it/id/eprint/13898

Collection description

Peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56, is reduced in subjects with new-onset type 1 diabetes (T1D). In three independent T1D cohorts, we find that low frequency of circulating TR3-56 cells is associated with reduced β-cell function and with the presence of diabetic ketoacidosis. We demonstrate that TR3-56 cells can suppress CD8+ T cell functions in vitro by reducing levels of intracellular reactive oxygen species. The suppressive function, phenotype and transcriptional signature of TR3-56 cells are also altered in T1D children. Together, our findings indicate that TR3-56 cells constitute a regulatory cell population that controls CD8+ effector functions, whose peripheral frequency may represent a traceable biomarker for monitoring immunological self-tolerance in T1D.

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