Fattorusso, Valentina (2021) T1D progression is associated with loss of CD3+CD56+regulatory cells. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | T1D progression is associated with loss of CD3+CD56+regulatory cells |
| Autori: | Autore Email Fattorusso, Valentina vfattorusso1@gmail.com |
| Data: | 11 Aprile 2021 |
| Numero di pagine: | 45 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email Franzese, Adriana [non definito] |
| Data: | 11 Aprile 2021 |
| Numero di pagine: | 45 |
| Parole chiave: | T1D, regulatory cells, c-peptide |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica |
| Depositato il: | 20 Apr 2021 07:41 |
| Ultima modifica: | 07 Giu 2023 13:20 |
| URI: | http://www.fedoa.unina.it/id/eprint/13898 |
Abstract
Peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56, is reduced in subjects with new-onset type 1 diabetes (T1D). In three independent T1D cohorts, we find that low frequency of circulating TR3-56 cells is associated with reduced β-cell function and with the presence of diabetic ketoacidosis. We demonstrate that TR3-56 cells can suppress CD8+ T cell functions in vitro by reducing levels of intracellular reactive oxygen species. The suppressive function, phenotype and transcriptional signature of TR3-56 cells are also altered in T1D children. Together, our findings indicate that TR3-56 cells constitute a regulatory cell population that controls CD8+ effector functions, whose peripheral frequency may represent a traceable biomarker for monitoring immunological self-tolerance in T1D.
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