PONSIGLIONE, ANDREA (2021) Role of serial cardiac 18F-FDG PET-MRI in Anderson-Fabry disease: a pilot study. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Role of serial cardiac 18F-FDG PET-MRI in Anderson-Fabry disease: a pilot study |
| Autori: | Autore Email PONSIGLIONE, ANDREA a.ponsiglionemd@gmail.com |
| Data: | 7 Dicembre 2021 |
| Numero di pagine: | 29 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Scienze biomorfologiche e chirurgiche |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Alberto, Cuocolo cuocolo@unina.it |
| Tutor: | nome email Imbriaco, Massimo [non definito] |
| Data: | 7 Dicembre 2021 |
| Numero di pagine: | 29 |
| Parole chiave: | Anderson-Fabry disease; PET/MRI; FASTEX score |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/36 - Diagnostica per immagini e radioterapia |
| Depositato il: | 20 Dic 2021 08:31 |
| Ultima modifica: | 28 Feb 2024 11:35 |
| URI: | http://www.fedoa.unina.it/id/eprint/14330 |
Abstract
Aim: We investigated the value of serial cardiac 18F-FDG PET-MRI in Anderson-Fabry disease (AFD) and the potential relationship of imaging results with FASTEX score. Methods and Results: Thirteen AFD patients underwent cardiac 18F-FDG PET-MRI at baseline and follow-up. Coefficient of variation (COV) of FDG uptake and FASTEX score were assessed. At baseline 9 patients were enzyme replacement therapy (ERT) naïve and 4 patients were under treatment. Two patients presented a FASTEX score of 0 indicating stable disease and did not show any imaging abnormality at baseline and follow-up PET-MRI. Eleven patients had a FASTEX score >20% indicating disease worsening. Four of these patients without late gadolinium enhancement (LGE) and with normal COV at baseline and follow-up had a FASTEX score of 35%. Three patients without LGE and with abnormal COV at baseline and follow-up had a FASTEX score ranging from 30% to 70%. Three patients with LGE and abnormal COV at baseline and follow-up had a FASTEX score between 35% and 75%. Finally, one patient with LGE and normal COV had a FASTEX score of 100%. Of the 12 patients on ERT at follow-up, FASTEX score was significantly higher in those 4 showing irreversible cardiac injury at baseline compared to 8 with negative LGE (66 ± 24 vs. 32 ± 21, P = 0.03). Conclusion: 18F-FDG PET-MRI may be effective to monitor cardiac involvement in AFD.
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