Monticolo, Francesco (2022) Functional genomics and bioinformatics approaches for the identification of cell fate molecular markers to implement diagnostic and monitoring devices in Food Science. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Functional genomics and bioinformatics approaches for the identification of cell fate molecular markers to implement diagnostic and monitoring devices in Food Science
Creators:
Creators
Email
Monticolo, Francesco
f.monticolo90@gmail.com
Date: 10 March 2022
Number of Pages: 270
Institution: Università degli Studi di Napoli Federico II
Department: Agraria
Dottorato: Scienze agrarie e agroalimentari
Ciclo di dottorato: 34
Coordinatore del Corso di dottorato:
nome
email
Barone, Amalia
ambarone@unina.it
Tutor:
nome
email
Chiusano, Maria Luisa
UNSPECIFIED
Date: 10 March 2022
Number of Pages: 270
Keywords: bioinformatics, natural compounds, programmed cell death
Settori scientifico-disciplinari del MIUR: Area 07 - Scienze agrarie e veterinarie > AGR/15 - Scienze e tecnologie alimentari
Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Date Deposited: 18 Mar 2022 10:41
Last Modified: 28 Feb 2024 10:41
URI: http://www.fedoa.unina.it/id/eprint/14460

Collection description

Cell fate is known to be an important aspect to consider in Food Science. Monitoring cell growth and limiting cell death are crucial for yield in industrial productions. It is crucial to consider gene expression as the earliest and fastest change in cell response. The analysis of gene expression provides direct insight into mRNA quantification. This information is fundamental for a better understanding of the early stages of cellular response. The project aims at the identification of early molecular markers that allow the prediction of cell fate in eukaryotic organisms: the unicellular eukaryote Saccharomyces cerevisiae and the multicellular organism Homo sapiens. The analyses here presented highlight the relevance of omics and bioinformatics application in monitoring cell growth, in the identification of molecular markers useful for the implementation of biosensors, and for the selection of natural compounds that could be exploited in the field of infectious diseases or cancer.

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