Casertano, Melania (2022) Selection of probiotic microorganisms with potential psychobiotic activity. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Selection of probiotic microorganisms with potential psychobiotic activity |
| Autori: | Autore Email Casertano, Melania melania.casertano@unina.it |
| Data: | 9 Marzo 2022 |
| Numero di pagine: | 136 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Agraria |
| Dottorato: | Scienze agrarie e agroalimentari |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Barone, Amalia ambarone@unina.it |
| Tutor: | nome email Ercolini, Danilo [non definito] Fogliano, Vincenzo [non definito] |
| Data: | 9 Marzo 2022 |
| Numero di pagine: | 136 |
| Parole chiave: | Psychobiotics, gut microbiota, mental health |
| Settori scientifico-disciplinari del MIUR: | Area 07 - Scienze agrarie e veterinarie > AGR/15 - Scienze e tecnologie alimentari |
| Depositato il: | 18 Mar 2022 10:40 |
| Ultima modifica: | 28 Feb 2024 14:24 |
| URI: | http://www.fedoa.unina.it/id/eprint/14497 |
Abstract
Psychobiotics include a novel class of probiotic microorganisms that convey benefit upon the host's mental health via the dynamic microbiota-gut-brain crosstalk. However, the specific probiotic strains and the way how they exert their beneficial effect still need to be investigated and assessed as well as their effects in the alleviation of stress and their effect on several cognitive performance domains. In this study we performed pre-clinical and clinical studies to I) evaluate the ability of probiotic strains to produce neurotransmitters in substrates enriched in precursors, II) investigate the interaction between the gut microbiota and the selected psychobiotic strains, III) assess the translatability of the psychobiotic activity of neurotransmitters-producing probiotics in a clinical intervention on healthy humans.
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