Fucile, Pierpaolo (2022) Design of Additive Manufactured Scaffolds with Tailored Morphology and Properties for Bone Tissue Regeneration. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Design of Additive Manufactured Scaffolds with Tailored Morphology and Properties for Bone Tissue Regeneration |
| Autori: | Autore Email Fucile, Pierpaolo pierpaolo.fucile@unina.it |
| Data: | 2022 |
| Numero di pagine: | 104 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Scienze biomorfologiche e chirurgiche |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Cuocolo, Alberto cuocolo@unina.it |
| Tutor: | nome email Improta, Giovanni [non definito] Russo, Teresa [non definito] Martorelli, Massimo [non definito] |
| Data: | 2022 |
| Numero di pagine: | 104 |
| Parole chiave: | Scaffolds for bone tissue regeneration; Design for Additive Manufacturing and Reverse Engineering; Design Methods |
| Settori scientifico-disciplinari del MIUR: | Area 09 - Ingegneria industriale e dell'informazione > ING-IND/15 - Disegno e metodi dell'ingegneria industriale Area 09 - Ingegneria industriale e dell'informazione > ING-IND/22 - Scienza e tecnologia dei materiali Area 09 - Ingegneria industriale e dell'informazione > ING-IND/34 - Bioingegneria industriale Area 09 - Ingegneria industriale e dell'informazione > ING-INF/06 - Bioingegneria elettronica e informatica |
| Depositato il: | 16 Mar 2022 11:26 |
| Ultima modifica: | 28 Feb 2024 10:19 |
| URI: | http://www.fedoa.unina.it/id/eprint/14623 |
Abstract
Tissue Engineering (TE), a highly interdisciplinary and multidisciplinary field which combines and merges efforts and knowledge from biology, engineering, medicine, and life science, aims to regenerate a damaged tissue, rather than replacing it, as it is typically done with conventional medical treatments. One of the main TE tools is the scaffold, which is a porous 3-Dimensional (3D) structure with controlled morphology and architecture. It guides and enhances the regeneration process, providing a 3D space for cells to grow into and create new tissue. A scaffold must mimic the Extra-Cellular Matrix of the tissue to be repaired, thus creating a favourable environment for cells to penetrate and potentially differentiate into the correct cell type. Scaffolds are typically realized through Additive Manufacturing (AM) technologies, in which objects are manufactured by adding material in a layer-by-layer fashion. AM techniques bring great advantages in terms of control over porosity (i.e., dimension and morphology) and interconnection. For the purpose of this thesis, many optimisation strategies towards the enhancement of extrusion-based AM processes will be investigated, as well as their implementation for the design and fabrication of porous scaffolds with tailorable morphology and properties for bone tissue regeneration.
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