Gaudieri, Valeria (2022) Relationship between peri-coronary adipose tissue, coronary atherosclerotic burden and coronary vascular function by 82Rb PET/CT imaging in patients with suspected coronary artery disease and normal MPI. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Relationship between peri-coronary adipose tissue, coronary atherosclerotic burden and coronary vascular function by 82Rb PET/CT imaging in patients with suspected coronary artery disease and normal MPI |
| Autori: | Autore Email Gaudieri, Valeria valeria.gaudieri@unina.it |
| Data: | 9 Dicembre 2022 |
| Numero di pagine: | 35 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Scienze biomorfologiche e chirurgiche |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Cuocolo, Alberto cuocolo@unina.it |
| Tutor: | nome email Cuocolo, Alberto [non definito] |
| Data: | 9 Dicembre 2022 |
| Numero di pagine: | 35 |
| Parole chiave: | Peri-coronary fat thickness, Myocardial perfusion reserve, Coronary vascular dysfunction |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/36 - Diagnostica per immagini e radioterapia |
| Depositato il: | 16 Dic 2022 18:24 |
| Ultima modifica: | 09 Apr 2025 14:07 |
| URI: | http://www.fedoa.unina.it/id/eprint/14688 |
Abstract
Aims Peri-coronary adipose tissue, due to its proximity to coronary arteries, has been proposed to contribute to the progression of coronary atherosclerosis, by releasing inflammatory mediators. We evaluated the relationship between peri-coronary fat thickness (PCFT), coronary artery calcium (CAC), myocardial blood flow (MBF) and myocardial perfusion reserve (MPR), in patients with suspected coronary artery disease (CAD) and normal myocardial perfusion imaging (MPI). Methods We studied 640 patients without overt CAD and with normal rest-stress 82Rb PET/CT MPI. MPR was considered reduced when < 2. CAC score was categorized as 0, < 400 or ≥ 400. PCFT was calculated on CT images as the maximum fat thickness (mm) between heart surface and visceral epicardium surrounding the main coronary arteries. Patients were stratified for body max index (BMI 30 kg/m2). Results Patients with MPR < 2 were significantly older, had higher prevalence of hypertension, diabetes and CAC ≥ 400, and showed significantly lower hyperemic MBF and higher PCFT values compared to those with normal MPR (all p < 0.001). Hyperemic MBF, MPR and PCFT values were related to extent of CAC (all p for trend < 0.001). In patients with CAC score 0 and with CAC score < 400, those with reduced MPR had significantly higher PCFT values than those with normal MPR (p < 0.001 and p 0.004, respectively). Conclusion In patients with suspected CAD and normal stress MPI, high PCFT values and coronary atherosclerotic burden are related to blunted hyperemic MBF and MPR. In patients with low CAC scores, PCFT was higher in patients with reduced MPR. PCFT could help to identify patients at risk of coronary vascular dysfunction.
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