Di Tolla, Michele Francesco (2024) Comparative Cytokine Dynamics: Unraveling the role of Lifestyle and Dietary Factors in shaping Low Grade Chronic Inflammation across Healthy and Neoplastic Profiles. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Comparative Cytokine Dynamics: Unraveling the role of Lifestyle and Dietary Factors in shaping Low Grade Chronic Inflammation across Healthy and Neoplastic Profiles. |
| Creators: | Creators Email Di Tolla, Michele Francesco michelefrancesco.ditolla@unina.it |
| Date: | 4 March 2024 |
| Number of Pages: | 85 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 36 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco frapagra@hotmail.com |
| Tutor: | nome email Formisano, Pietro UNSPECIFIED |
| Date: | 4 March 2024 |
| Number of Pages: | 85 |
| Keywords: | LGCI, Cytokines, Lifestyle, Inflammation |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/05 - Patologia clinica |
| Date Deposited: | 15 Mar 2024 10:19 |
| Last Modified: | 14 Apr 2026 06:55 |
| URI: | http://www.fedoa.unina.it/id/eprint/15562 |
Collection description
Low Grade Chronic Inflammation (LGCI) is a common feature of noncommunicable diseases. Cytokines play a crucial role in LGCI. This study aimed to assess how LGCI risk factors [e.g., age, body mass index (BMI), smoke, physical activity, and diet] may impact on specific cytokine levels in both healthy and neoplastic populations. In total, 150 healthy volunteers and 132 neoplastic patients were recruited and subjected to questionnaires about the last 7-days lifestyle, including smoking habit, physical activity, and food frequency. A panel of circulating cytokines, chemokines, growth factors, metabolic markers and adipokines was analyzed by multiplex ELISA. In healthy patients, BMI showed the heaviest impact on the correlation between LGCI-related risk factors and cytokines and was significantly associated with CRP levels. BMI, along with aging, smoking, physical activity, and eating habits were associated with an inflammatory pattern, characterized by a cluster that included IL-1β, IL-6, IL-8 and TNF-α. These markers retained their strong clustering feature in the neoplastic population, with the addition of other inflammatory markers, such as MIP-1α, MIP-1β, IL-4, and GM-CSF. In conclusion, BMI, age, smoke, physical activity, and dietary habits are associated with specific cytokines that may represent potential markers for LGCI, and a first proof of this biomarker validation is given by the reappearance of this cluster in a neoplastic population.
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