Prognosis and adjuvant treatment effects in very young women (below 35 years) with operable breast cancer

Cancello, Giuseppe (2009) Prognosis and adjuvant treatment effects in very young women (below 35 years) with operable breast cancer. [Tesi di dottorato] (Inedito)

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Abstract

Background: There is limited knowledge about prognosis of selected breast cancer subtypes among very young women Patients and Methods: We explored patterns of recurrence by age according to four immunohistochemically-defined tumor subtypes: triple negative, HER2 positive (and) endocrine receptor absent, Luminal A and Luminal B (ER-positive and/or PR-positive and either HER2-positive and/or high Ki67) in 2970 premenopausal patients with pT1-3, pN0-3 and M0 breast cancer. Results: Patients below 35 years of age (315, 11%) presented a significantly increased risk of recurrence and death (HR=1.65, 95%CI 1.30-2.10 and HR=1.78, 95%CI 1.12-2.85, respectively) when compared with older patients (2655, 89%) with similar characteristics of disease. This was true considering patients with luminal B (HR 1.62, 95%CI, 1.21-2.18, for DFS; HR 2.09, 95%CI, 0.96-4.53, for OS) and with triple-negative (HR 2.04, 95%CI, 1.11-3.72, for DFS; HR 2.20, 95%CI, 1.10-4.41, for OS) breast cancer, observing the highest risk of recurrence in the younger patients with HER2 positive breast cancer (HR 2.37, 95% CI, 1.12-5.02), when compared with older patients. Conclusions: Very young patients with triple negative, luminal B, or HER2 positive breast cancer have a worse prognosis when compared with older patients with similar characteristics of disease.

Tipologia di documento:Tesi di dottorato
Parole chiave:breast cancer; immunohistochemistry; very young women
Settori scientifico-disciplinari MIUR:Area 06 Scienze mediche > MED/06 ONCOLOGIA MEDICA
Coordinatori della Scuola di dottorato:
Coordinatore del Corso di dottoratoe-mail (se nota)
Vecchio, Giancarlovecchio@unina.it
Tutor della Scuola di dottorato:
Tutor del Corso di dottoratoe-mail (se nota)
De Placido, Sabinosdponco@unina.it
Stato del full text:Accessibile
Data:27 Novembre 2009
Numero di pagine:39
Istituzione:Università degli Studi di Napoli Federico II
Dipartimento o Struttura:Biologia e Patologia Cellulare e Molecolare "Luigi Califano"
Tipo di tesi:Dottorato
Stato dell'Eprint:Inedito
Scuola di dottorato:Medicina Molecolare
Denominazione del dottorato:Oncologia ed Endocrinologia Molecolare
Ciclo di dottorato:XXII
Numero di sistema:3942
Depositato il:27 Maggio 2010 16:48
Ultima modifica:13 Luglio 2012 11:08

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