CROSS-TALK BETWEEN ENDOCRINE SYSTEM AND OTHER BIOLOGICAL PATHWAYS: PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS IN PAEDIATRIC ENDOCRINOPATHIES

Capalbo, Donatella (2009) CROSS-TALK BETWEEN ENDOCRINE SYSTEM AND OTHER BIOLOGICAL PATHWAYS: PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS IN PAEDIATRIC ENDOCRINOPATHIES. [Tesi di dottorato] (Inedito)

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Abstract

Endocrine system exerts relevant effects on multiple organs and tissues. Pleiotropic and redundant functions of circulating hormones are due to the various receptors expressed on multiple target cells. Moreover, receptors of circulating hormones share common transducing elements with receptors of many other molecules. Consequently, endocrine system participate to an integrated network of mediators that communicate and coordinate responsive cells to achive effective functions in an appropriate fashion. The presence of such a complex interplay contribute to unravel previously unappreciated functions of circulating hormones and the mechanisms of coordination and integration of several pathways. An example of this interplay is the complex interaction between endocrine and immune system. Cytokines and growth factors, in fact, after their binding to cell-surface receptos, activate common intracytoplasmatic signaling molecules. In the recent years the description of complex phenotypes, in which immunodeficiency and growth failure were associated at a different extent, greatly contributed to define how several signaling molecules play a role in both systems. As well as immunodeficiency, autoimmune diseases represent a unique model to study interactions between endocrine and immune systems. Cardiovascular system also represents a biological system higly sensitive to the effects of circulating hormones as suggested by the presence of several cardiovascular and metabolic alterations found in many endocrine diseases. In fact, patient with growth hormone deficiency as well as thyroid dysfunction, may present an increased morbidity due to cardiovascular events and an increased incidence of atherosclerosis. Aim of this project was to evaluate physiological and pathological implications of these complex molecular interactions on paediatric endocrinopathies starting from complex phenotype involving endocrine and other biological systems. To this aim, we started from the study of 3 model of complex diseases: • The model of autoimmune diseases • The model of Growth Hormone (GH) Deficiency (GHD) • The model of Congenital Hypothyroidism (CH) Moreover, during the study of patients affected with Growth Hormone and thyroid disorders we also identified new genetic causes of GH deficiency and hyperthyroidism, highlithing new insights in the genetics of endocrine diseases, as described in the last chapter of the thesis.

Tipologia di documento:Tesi di dottorato
Parole chiave:Autoimmunity, APECED, Hypothyroidism, GH Deficiency
Settori scientifico-disciplinari MIUR:Area 06 Scienze mediche > MED/38 PEDIATRIA GENERALE E SPECIALISTICA
Coordinatori della Scuola di dottorato:
Coordinatore del Corso di dottoratoe-mail (se nota)
Pignata, Claudio
Tutor della Scuola di dottorato:
Tutor del Corso di dottoratoe-mail (se nota)
Salerno, Mariacarolinasalerno@unina.it
Stato del full text:Accessibile
Data:30 Novembre 2009
Numero di pagine:167
Istituzione:Università degli Studi di Napoli Federico II
Dipartimento o Struttura:Pediatria
Tipo di tesi:Dottorato
Stato dell'Eprint:Inedito
Scuola di dottorato:Medicina Clinica e Sperimentale
Denominazione del dottorato:Riproduzione, Sviluppo ed Accrescimento dell'Uomo
Ciclo di dottorato:XXII
Numero di sistema:4253
Depositato il:02 Dicembre 2009 14:26
Ultima modifica:28 Luglio 2010 12:32

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