Celentano, Luigi, Laccetti, Paolo, Marotta, Marcello, Mettivier, Giovanni, Quarto, Maria, Riccio, Patrizia, Roberti, Giuseppe and Russo, Paolo (2007) Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395. [Pubblicazione in rivista scientifica]

Full text not available from this repository.
Item Type: Pubblicazione in rivista scientifica
Resource language: English
Title: Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395.
Creators:
Creators
Email
Celentano, Luigi
UNSPECIFIED
Laccetti, Paolo
UNSPECIFIED
Marotta, Marcello
UNSPECIFIED
Mettivier, Giovanni
UNSPECIFIED
Quarto, Maria
UNSPECIFIED
Riccio, Patrizia
UNSPECIFIED
Roberti, Giuseppe
UNSPECIFIED
Russo, Paolo
UNSPECIFIED
Autore/i: M. Autiero, L. Celentano, R. Cozzolino, P. Laccetti, M. Marotta, G. Mettivier, M. Quarto, P. Riccio, G. Roberti, P. Russo
Date: 2007
Number of Pages: 3
Department: Scienze fisiche
Identification Number: 10.1016/j.nima.2006.10.117
Journal or Publication Title: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT
Date: 2007
Volume: 571
Page Range: pp. 392-395
Number of Pages: 3
Identification Number: 10.1016/j.nima.2006.10.117
Date Deposited: 20 Oct 2010 08:34
Last Modified: 30 Apr 2014 19:42
URI: http://www.fedoa.unina.it/id/eprint/6844

Collection description

We investigated the capability of fluorescence reflectance imaging (FRI) for the early detection of surface tumors in mice. We used a hematoporphyrin (HP) compound (HP dichlorohydrate) as a red fluorescent marker and a low noise, high sensitivity, digital CCD camera for fluorescence imaging. In this preliminary study, highly malignant anaplastic human thyroid carcinoma cells were implanted subcutaneously in one mouse and their growth was monitored daily for 5 days by FRI. The selective HP uptake by the tumor tissues was successfully observed: we observed the fluorescence of tumor only 3 days after cancer cells injection, i.e. when the tumor mass was neither visible (to the naked eye) or palpable. These measurements indicate that FRI is a suitable technique to detect minute subcutaneous tumor masses. This FRI system will be coupled to a radionuclide imaging system based on a CdTe detector for in vivo multimodal imaging in mice.

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