Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395.
CELENTANO, LUIGI and LACCETTI, PAOLO and MAROTTA, MARCELLO and METTIVIER, GIOVANNI and QUARTO, MARIA and RICCIO, PATRIZIA and ROBERTI, GIUSEPPE and RUSSO, PAOLO (2007) Early detection of tumor masses by in vivo hematoporphirin-mediated fluorescente imaging. 2007. Nuclear Instruments and Methods in Physics Research A 571: 392-395. [Pubblicazione su rivista scientifica]
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We investigated the capability of fluorescence reflectance imaging (FRI) for the early detection of surface tumors in mice. We used a hematoporphyrin (HP) compound (HP dichlorohydrate) as a red fluorescent marker and a low noise, high sensitivity, digital CCD camera for fluorescence imaging. In this preliminary study, highly malignant anaplastic human thyroid carcinoma cells were implanted subcutaneously in one mouse and their growth was monitored daily for 5 days by FRI. The selective HP uptake by the tumor tissues was successfully observed: we observed the fluorescence of tumor only 3 days after cancer cells injection, i.e. when the tumor mass was neither visible (to the naked eye) or palpable. These measurements indicate that FRI is a suitable technique to detect minute subcutaneous tumor masses. This FRI system will be coupled to a radionuclide imaging system based on a CdTe detector for in vivo multimodal imaging in mice.
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