Della Vittoria Scarpati, Giuseppina (2010) New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer. [Tesi di dottorato] (Inedito)

[img]
Anteprima
PDF
della_vittoria_scarpati_giuseppina_23.pdf

Download (1MB) | Anteprima
Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer
Autori:
AutoreEmail
Della Vittoria Scarpati, Giuseppinagiuseppina.dellavittoria@alice.it
Data: 29 Novembre 2010
Numero di pagine: 54
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Endocrinologia ed oncologia molecolare e clinica
Scuola di dottorato: Medicina molecolare
Dottorato: Oncologia ed endocrinologia molecolare
Ciclo di dottorato: 23
Coordinatore del Corso di dottorato:
nomeemail
Santoro, Massimo[non definito]
Tutor:
nomeemail
Pepe, Stefanostepepe@unina.it
Cerrato, Aniello[non definito]
Data: 29 Novembre 2010
Numero di pagine: 54
Parole chiave: colorectal cancer, prognostic and predictive factors, microRNA
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/06 - Oncologia medica
Depositato il: 13 Dic 2010 14:38
Ultima modifica: 30 Apr 2014 19:44
URI: http://www.fedoa.unina.it/id/eprint/8143
DOI: 10.6092/UNINA/FEDOA/8143

Abstract

microRNAs are small single-stranded RNA molecules of approximately 22 nucleotides that function as post-transcriptional gene regulators. MiRNAs play important roles in the control of many biological processes, such as cellular development, differentiation, proliferation, apoptosis and metabolism. miRNA expression is aberrant in several human tumors. The biologic roles of miRNAs in cancer suggest a correlation with prognosis and therapeutic outcome. In our study, we examined by microarray the expression of 939 miRNArole in fresh biopsies of 39 patients affected by local advanced rectal cancer, treated with neoadjuvant chemoradiotherapy and surgery, with the aim to investigate the possible predictive and prognostic role. We have identified 14 miRNA which correlate significantly with Tumor Regression Grade 1. Our results suggest that miRNA expression profile could have relevance as prognostic and predictive factor of response to chemo-radiotherapy in colo-rectal cancer.

Actions (login required)

Modifica documento Modifica documento