Della Vittoria Scarpati, Giuseppina (2010) New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer. [Tesi di dottorato] (Unpublished)

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Item Type: Tesi di dottorato
Lingua: English
Title: New biomolecular prognostic and predictive factors of response to treatment in colo-rectal cancer
Creators:
CreatorsEmail
Della Vittoria Scarpati, Giuseppinagiuseppina.dellavittoria@alice.it
Date: 29 November 2010
Number of Pages: 54
Institution: Università degli Studi di Napoli Federico II
Department: Endocrinologia ed oncologia molecolare e clinica
Scuola di dottorato: Medicina molecolare
Dottorato: Oncologia ed endocrinologia molecolare
Ciclo di dottorato: 23
Coordinatore del Corso di dottorato:
nomeemail
Santoro, MassimoUNSPECIFIED
Tutor:
nomeemail
Pepe, Stefanostepepe@unina.it
Cerrato, AnielloUNSPECIFIED
Date: 29 November 2010
Number of Pages: 54
Uncontrolled Keywords: colorectal cancer, prognostic and predictive factors, microRNA
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/06 - Oncologia medica
Date Deposited: 13 Dec 2010 14:38
Last Modified: 30 Apr 2014 19:44
URI: http://www.fedoa.unina.it/id/eprint/8143
DOI: 10.6092/UNINA/FEDOA/8143

Abstract

microRNAs are small single-stranded RNA molecules of approximately 22 nucleotides that function as post-transcriptional gene regulators. MiRNAs play important roles in the control of many biological processes, such as cellular development, differentiation, proliferation, apoptosis and metabolism. miRNA expression is aberrant in several human tumors. The biologic roles of miRNAs in cancer suggest a correlation with prognosis and therapeutic outcome. In our study, we examined by microarray the expression of 939 miRNArole in fresh biopsies of 39 patients affected by local advanced rectal cancer, treated with neoadjuvant chemoradiotherapy and surgery, with the aim to investigate the possible predictive and prognostic role. We have identified 14 miRNA which correlate significantly with Tumor Regression Grade 1. Our results suggest that miRNA expression profile could have relevance as prognostic and predictive factor of response to chemo-radiotherapy in colo-rectal cancer.

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