Lania, Giuliana (2011) biological effect of P31-43. [Tesi di dottorato] (Inedito)

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: biological effect of P31-43
Autori:
AutoreEmail
Lania, Giulianagiuliana.lania@gmail.com
Data: 28 Novembre 2011
Numero di pagine: 138
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Pediatria
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Riproduzione, sviluppo ed accrescimento dell'uomo
Ciclo di dottorato: 24
Coordinatore del Corso di dottorato:
nomeemail
Pignata, Claudio[non definito]
Tutor:
nomeemail
Barone, Maria Vittoriamv.barone@unina.it
Data: 28 Novembre 2011
Numero di pagine: 138
Parole chiave: celiac desease, gliadin peptide, endocytosis
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 05 - Scienze biologiche > BIO/17 - Istologia
Area 05 - Scienze biologiche > BIO/10 - Biochimica
Area 06 - Scienze mediche > MED/12 - Gastroenterologia
Depositato il: 07 Dic 2011 11:26
Ultima modifica: 17 Giu 2014 06:04
URI: http://www.fedoa.unina.it/id/eprint/8601

Abstract

Celiac disease (CD) is an intolerance to wheat gliadin and prolamine present also in barley and rye. The intake of these cereals in the diet determines, in the small intestine, a cellular and humoral immune response in people genetically predisposed. Diagnosis of celiac disease was based, in the past, mainly on the clinic manifestations and the prevalence of the disease, which was considered rare, around 1:1000, with large differences in incidence in different geographical areas. Thanks to recent studies based on serological tests (EMA and tTG2 antibodies) it was found that celiac disease has a prevalence of around 1:100, even in those European countries such as Denmark and the Netherlands, where the estimation of the disease was known to be very low, or in the United States, where it was believed that the disease almost did not exist. This reversal of the situation can be explained by the "iceberg model", originally introduced by R. Logan in 1991, in which the visible part of the iceberg corresponds to the cases of celiac disease diagnosed because clinically evident, while the submerged part is represented by the cases not diagnosed because asymptomatic or "atypical". Furthermore, a delayed introduction of gluten in the diet, instead of preventing the development of celiac disease, as it was thought at the beginning, did nothing but increase the "atypical" onset of disease. Likely factors such as age of introduction of gluten in the diet and its quantity may influence the clinical presentation of celiac disease

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