Paolella, Concetta (2011) DESIGN AND SYNTHESIS OF NEW SELECTIVE CHEMOTHERAPEUTIC AGENTS. [Tesi di dottorato] (Unpublished)

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Item Type: Tesi di dottorato
Language: English
Title: DESIGN AND SYNTHESIS OF NEW SELECTIVE CHEMOTHERAPEUTIC AGENTS
Creators:
CreatorsEmail
Paolella, Concettaconcetta.paolella@unina.it
Date: 30 November 2011
Number of Pages: 169
Institution: Università degli Studi di Napoli Federico II
Department: Chimica organica e biochimica
Doctoral School: Scienze chimiche
PHD name: Scienze chimiche
PHD cycle: 24
PHD Coordinator:
nameemail
Previtera, Luciolucio.previtera@unina.it
Tutor:
nameemail
Guaragna, Annalisaannalisa.guaragna@unina.it
Palumbo, Giovannigiovanni.palumbo@unina.it
Date: 30 November 2011
Number of Pages: 169
Uncontrolled Keywords: Drug delivery systems, folic acid conjugates, antitumor therapy, nucleoside analogues, 4'-substituted nucleosides analogues, sugar modified nucleosides, modified oligonucleotides, antiviral
MIUR S.S.D.: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 07 Dec 2011 08:47
Last Modified: 30 Apr 2014 19:49
URI: http://www.fedoa.unina.it/id/eprint/8918

Abstract

Synthesis of selective chemotherapeutic agents for antitumor and antiviral therapy purposes has been herein accomplished. Particularly, some novel molecular systems have been developed: Folic acid based chlorambucil conjugates for selective antitumor treatments. Folic acid based 5-aminolevulinic acid derivatives for photodynamic therapy of tumor cells. 4'-Substituted nucleosides and 2'3'-dihydro-1,4-dithiinyl nucleosides analogues for antiviral therapies. Six-membered sugar based modified oligonucleotides: ribo-CNA, (ribo-Cyclohexanyl Nucleic Acids)for gene expression control.

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