Paolella, Concetta (2011) DESIGN AND SYNTHESIS OF NEW SELECTIVE CHEMOTHERAPEUTIC AGENTS. [Tesi di dottorato] (Unpublished)
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | DESIGN AND SYNTHESIS OF NEW SELECTIVE CHEMOTHERAPEUTIC AGENTS |
| Creators: | Creators Email Paolella, Concetta concetta.paolella@unina.it |
| Date: | 30 November 2011 |
| Number of Pages: | 169 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Chimica organica e biochimica |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 24 |
| Coordinatore del Corso di dottorato: | nome email Previtera, Lucio lucio.previtera@unina.it |
| Tutor: | nome email Guaragna, Annalisa annalisa.guaragna@unina.it Palumbo, Giovanni giovanni.palumbo@unina.it |
| Date: | 30 November 2011 |
| Number of Pages: | 169 |
| Keywords: | Drug delivery systems, folic acid conjugates, antitumor therapy, nucleoside analogues, 4'-substituted nucleosides analogues, sugar modified nucleosides, modified oligonucleotides, antiviral |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Date Deposited: | 07 Dec 2011 08:47 |
| Last Modified: | 30 Apr 2014 19:49 |
| URI: | http://www.fedoa.unina.it/id/eprint/8918 |
| DOI: | 10.6092/UNINA/FEDOA/8918 |
Collection description
Synthesis of selective chemotherapeutic agents for antitumor and antiviral therapy purposes has been herein accomplished. Particularly, some novel molecular systems have been developed: Folic acid based chlorambucil conjugates for selective antitumor treatments. Folic acid based 5-aminolevulinic acid derivatives for photodynamic therapy of tumor cells. 4'-Substituted nucleosides and 2'3'-dihydro-1,4-dithiinyl nucleosides analogues for antiviral therapies. Six-membered sugar based modified oligonucleotides: ribo-CNA, (ribo-Cyclohexanyl Nucleic Acids)for gene expression control.
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