Schiattarella, Maria (2013) Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid
Creators:
CreatorsEmail
Schiattarella, Mariamschiat@libero.it
Date: 27 March 2013
Number of Pages: 33
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Clinica e Chirurgia
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Fisiopatologia clinica e medicina sperimentale
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Marone, GianniUNSPECIFIED
Tutor:
nomeemail
Ayala, FabioUNSPECIFIED
Date: 27 March 2013
Number of Pages: 33
Uncontrolled Keywords: Interleukin-1 family, psoriasis, inflammation, vitamin D, retinoic acid, immune regulation
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree
Date Deposited: 11 Apr 2013 10:17
Last Modified: 31 Dec 2016 02:00
URI: http://www.fedoa.unina.it/id/eprint/9146

Abstract

Interleukin (IL)-1 family comprise 11 members that plays an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs). In the present study we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.

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