Schiattarella, Maria (2013) Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid. [Tesi di dottorato]
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tesi dottorato Maria Schiattarella.pdf Download (1MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid |
| Autori: | Autore Email Schiattarella, Maria mschiat@libero.it |
| Data: | 27 Marzo 2013 |
| Numero di pagine: | 33 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Clinica e Chirurgia |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Fisiopatologia clinica e medicina sperimentale |
| Ciclo di dottorato: | 25 |
| Coordinatore del Corso di dottorato: | nome email Marone, Gianni [non definito] |
| Tutor: | nome email Ayala, Fabio [non definito] |
| Data: | 27 Marzo 2013 |
| Numero di pagine: | 33 |
| Parole chiave: | Interleukin-1 family, psoriasis, inflammation, vitamin D, retinoic acid, immune regulation |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree |
| Depositato il: | 11 Apr 2013 10:17 |
| Ultima modifica: | 31 Dic 2016 02:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/9146 |
Abstract
Interleukin (IL)-1 family comprise 11 members that plays an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs). In the present study we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.
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