Schiattarella, Maria
(2013)
Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid |
| Autori: |
| Autore | Email |
|---|
| Schiattarella, Maria | mschiat@libero.it |
|
| Data: |
27 Marzo 2013 |
| Numero di pagine: |
33 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Medicina Clinica e Chirurgia |
| Scuola di dottorato: |
Medicina clinica e sperimentale |
| Dottorato: |
Fisiopatologia clinica e medicina sperimentale |
| Ciclo di dottorato: |
25 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Marone, Gianni | [non definito] |
|
| Tutor: |
| nome | email |
|---|
| Ayala, Fabio | [non definito] |
|
| Data: |
27 Marzo 2013 |
| Numero di pagine: |
33 |
| Parole chiave: |
Interleukin-1 family, psoriasis, inflammation, vitamin D, retinoic acid, immune regulation |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree |
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| Depositato il: |
11 Apr 2013 10:17 |
| Ultima modifica: |
31 Dic 2016 02:00 |
| URI: |
http://www.fedoa.unina.it/id/eprint/9146 |
Abstract
Interleukin (IL)-1 family comprise 11 members that plays an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs).
In the present study we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members.
We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD.
IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.
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