Squeglia, Flavia (2013) Structural and functional characterization of proteins involved in bacterial cell growth and division. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Structural and functional characterization of proteins involved in bacterial cell growth and division
Creators:
CreatorsEmail
Squeglia, Flaviasquegliaflavia@gmail.com
Date: 28 March 2013
Number of Pages: 87
Institution: Università degli Studi di Napoli Federico II
Department: Chimica organica e biochimica
Scuola di dottorato: Scienze chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 25
Coordinatore del Corso di dottorato:
nomeemail
Previtera, Luciopreviter@unina.it
Tutor:
nomeemail
D'Auria, Gabriellagabriella.dauria@unina.it
Berisio, Ritarita.berisio@unina.it
Date: 28 March 2013
Number of Pages: 87
Uncontrolled Keywords: Cell wall division, Peptidoglycan, RipA, PrkC
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/10 - Biochimica
Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 05 - Scienze biologiche > BIO/19 - Microbiologia generale
Date Deposited: 05 Apr 2013 06:10
Last Modified: 04 Jul 2014 11:29
URI: http://www.fedoa.unina.it/id/eprint/9230

Abstract

In my Ph.D. project I focus attention on proteins involved in cell wall division and regulation of revival from dormancy in different kind of bacteria. Ph.D. thesis consists in two parts. PART I describes structural and biochemical studies on Resuscitation Promoting factor Interacting Protein A RipA, an enzyme essential for cell division in Mycobacterium tuberculosis. We have investigated RipA function by combining atomic structure characterization, circular dichroism (CD), fluorescence spectroscopy and mass spectroscopy. PART II describes structural and functional investigations on two proteins involved in regulation of cell wall division and resuscitation form dormancy, the serine/threonine kinases PrkC from Staphylococcus aureus and Bacillus subtilis and the Penicillin Binding Protein PonA2 from Mycobacterium tuberculosis.

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