Squeglia, Flavia (2013) Structural and functional characterization of proteins involved in bacterial cell growth and division. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Structural and functional characterization of proteins involved in bacterial cell growth and division |
| Creators: | Creators Email Squeglia, Flavia squegliaflavia@gmail.com |
| Date: | 28 March 2013 |
| Number of Pages: | 87 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Chimica organica e biochimica |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 25 |
| Coordinatore del Corso di dottorato: | nome email Previtera, Lucio previter@unina.it |
| Tutor: | nome email D'Auria, Gabriella gabriella.dauria@unina.it Berisio, Rita rita.berisio@unina.it |
| Date: | 28 March 2013 |
| Number of Pages: | 87 |
| Keywords: | Cell wall division, Peptidoglycan, RipA, PrkC |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 05 - Scienze biologiche > BIO/19 - Microbiologia generale |
| Date Deposited: | 05 Apr 2013 06:10 |
| Last Modified: | 04 Jul 2014 11:29 |
| URI: | http://www.fedoa.unina.it/id/eprint/9230 |
Collection description
In my Ph.D. project I focus attention on proteins involved in cell wall division and regulation of revival from dormancy in different kind of bacteria. Ph.D. thesis consists in two parts. PART I describes structural and biochemical studies on Resuscitation Promoting factor Interacting Protein A RipA, an enzyme essential for cell division in Mycobacterium tuberculosis. We have investigated RipA function by combining atomic structure characterization, circular dichroism (CD), fluorescence spectroscopy and mass spectroscopy. PART II describes structural and functional investigations on two proteins involved in regulation of cell wall division and resuscitation form dormancy, the serine/threonine kinases PrkC from Staphylococcus aureus and Bacillus subtilis and the Penicillin Binding Protein PonA2 from Mycobacterium tuberculosis.
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