Durante, Lorenzo (2014) Identification, production and structural modelling of cationic antimicrobial peptides (CAMPs). [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Identification, production and structural modelling of cationic antimicrobial peptides (CAMPs) |
| Creators: | Creators Email Durante, Lorenzo l.durante@studenti.unina.it |
| Date: | 31 March 2014 |
| Number of Pages: | 102 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Medicina Molecolare e Biotecnologie Mediche |
| Scuola di dottorato: | Biotecnologie |
| Dottorato: | Biologia computazionale e bioinformatica |
| Ciclo di dottorato: | 26 |
| Coordinatore del Corso di dottorato: | nome email Cocozza, Sergio cocozza@unina.it |
| Tutor: | nome email Notomista, Eugenio UNSPECIFIED |
| Date: | 31 March 2014 |
| Number of Pages: | 102 |
| Keywords: | antimicrobial peptides; Monte Carlo; recombinant peptide |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica |
| Additional information: | Il lavoro è stato svolto presso il Dipartimento di Biologia |
| Date Deposited: | 07 Apr 2014 13:29 |
| Last Modified: | 15 Jul 2015 01:02 |
| URI: | http://www.fedoa.unina.it/id/eprint/9962 |
Collection description
This work is part of the wide field of research on cationic antimicrobial peptides (CAMPs), molecules of great therapeutical potential for their antibacterial action, directed also against multi-drug resistant strains. By using a panel of bioinformatic, experimental and computational techniques, three novel tools were developed: (1) a scoring function, which allows the identification of putative CAMPs inside protein sequences and permits to perform strain-specific researches; (2) a fusion construct for the expression of recombinant CAMPs, which allows to prepare high purity peptides of variable length in high yields; (3) methods for the modelling of CAMPs by means of the Monte Carlo strategy and implicit solvation energy functions.
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