Durante, Lorenzo (2014) Identification, production and structural modelling of cationic antimicrobial peptides (CAMPs). [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Identification, production and structural modelling of cationic antimicrobial peptides (CAMPs)
Creators:
Creators
Email
Durante, Lorenzo
l.durante@studenti.unina.it
Date: 31 March 2014
Number of Pages: 102
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Molecolare e Biotecnologie Mediche
Scuola di dottorato: Biotecnologie
Dottorato: Biologia computazionale e bioinformatica
Ciclo di dottorato: 26
Coordinatore del Corso di dottorato:
nome
email
Cocozza, Sergio
cocozza@unina.it
Tutor:
nome
email
Notomista, Eugenio
UNSPECIFIED
Date: 31 March 2014
Number of Pages: 102
Keywords: antimicrobial peptides; Monte Carlo; recombinant peptide
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/10 - Biochimica
Additional information: Il lavoro è stato svolto presso il Dipartimento di Biologia
Date Deposited: 07 Apr 2014 13:29
Last Modified: 15 Jul 2015 01:02
URI: http://www.fedoa.unina.it/id/eprint/9962

Collection description

This work is part of the wide field of research on cationic antimicrobial peptides (CAMPs), molecules of great therapeutical potential for their antibacterial action, directed also against multi-drug resistant strains. By using a panel of bioinformatic, experimental and computational techniques, three novel tools were developed: (1) a scoring function, which allows the identification of putative CAMPs inside protein sequences and permits to perform strain-specific researches; (2) a fusion construct for the expression of recombinant CAMPs, which allows to prepare high purity peptides of variable length in high yields; (3) methods for the modelling of CAMPs by means of the Monte Carlo strategy and implicit solvation energy functions.

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