Campione, Severo
(2017)
THE CONTRIBUTION OF PATHOLOGICAL EVALUATION OF MUCOSAL HEALING IN THE MANAGEMENT OF PATIENTS AFFECTED BY INFLAMMATORY BOWEL DISEASES.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
THE CONTRIBUTION OF PATHOLOGICAL EVALUATION OF MUCOSAL HEALING IN THE MANAGEMENT OF PATIENTS AFFECTED BY INFLAMMATORY BOWEL DISEASES |
| Autori: |
| Autore | Email |
|---|
| Campione, Severo | severo@gmx.de |
|
| Data: |
29 Settembre 2017 |
| Numero di pagine: |
31 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
dep18 |
| Dottorato: |
phd076 |
| Ciclo di dottorato: |
30 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Cuocolo, Alberto | cuocolo@unina.it |
|
| Tutor: |
| nome | email |
|---|
| D'Armiento, Maria | [non definito] |
|
| Data: |
29 Settembre 2017 |
| Numero di pagine: |
31 |
| Parole chiave: |
Pathology
Inflammatory bowel disease
Mucosal Healing |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/08 - Anatomia patologica |
[error in script]
[error in script]
| Depositato il: |
18 Dic 2017 12:23 |
| Ultima modifica: |
10 Apr 2019 10:45 |
| URI: |
http://www.fedoa.unina.it/id/eprint/12062 |
Abstract
Introduction: Mucosal Healing (MH) is becoming an increasing tool in the management of patients affected by inflammatory bowel diseases and is set as the endpoint of a therapy in clinical trials, especially for the recently introduced biological agents.
MH is evaluated by direct investigation instruments and in most clinical trials these are represented by endoscopy.
There is no definition of MH in pathology and there are no established evaluation criteria of MH among pathologists.
Aim of this study is to find a pathological definition of MH and a pathological score as useful as endoscopy scores to the clinical management.
Methods: a population of 51 patients in pediatric age is selected, affected by both Crohn’s disease and ulcerative colitis, and is treated for 1 year with Azathioprine. All patients undergo colonoscopy with biopsies at the beginning and at the end of the therapy. Patients are followed for 2 years after the end of the trial and some of them have biopsy follow up. Biopsies are evaluated with two different scores, the Combined Architectural and Inflammatory Score and the Activity Score in order to evaluate MH. An immunohistochemical analysis is also performed. Results are correlated with Endoscopy and follow up.
Conclusions: Among the two scores, the Activity Score exhibited higher correlation with endoscopy, demonstrating the usefulness of pathological MH. Moreover, both scores produced a significant prediction of release during follow up.
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