Fiordelisi, Antonella (2020) Identification of novel molecular mechanisms and therapeutic strategy in cardiovascular diseases (CVD). [Tesi di dottorato]

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: Identification of novel molecular mechanisms and therapeutic strategy in cardiovascular diseases (CVD)
Autori:
AutoreEmail
Fiordelisi, Antonellaantonella.fiordelisi@gmail.com
Data: 20 Ottobre 2020
Numero di pagine: 45
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Scienze Biomediche Avanzate
Dottorato: Cardiovascular Pathophysiology and Therapeutics
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
nomeemail
Barbato, Emanuelebarba22@hotmail.com
Tutor:
nomeemail
Barbato, Emanuele[non definito]
Data: 20 Ottobre 2020
Numero di pagine: 45
Parole chiave: cardiovascular diseases; GRK2; inflammation
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare
Depositato il: 19 Ott 2020 10:29
Ultima modifica: 28 Ott 2021 12:08
URI: http://www.fedoa.unina.it/id/eprint/13269

Abstract

Research studies in cardiovascular diseases (CVD) field allowed the identification of several molecular mechanisms and novel therapeutic drugs. In this context, inflammation plays a key role in the development of CVD. In particular, GRK2 a serine/threonine kinases is abundant in the heart and is a critical regulator of cardiac function. Indeed, GRK2 regulates NFkappaB that it represents a functional bridge between inflammation and cardiac pathologies. Moreover, GRK2 is also important for evolution of endothelium, which exerts a crucial role in maintaining vascular integrity. In addition, GRK2 is critical to preserve mitochondrial integrity and favor cardiac cell survival. Several other contributors to CVD have been identified, such as air pollution. Clinical and epidemiological studies demonstrate that short- and long-term exposure to air pollution increases mortality due to respiratory and cardiovascular diseases. Also, anthracyclines, the most effective antineoplastic drugs, exert a dosedependent cardiotoxic effect leading to irreversible heart failure. Further studies will be needed to better explore these issues but these data have great translational potentiality with important clinical implications.

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