Lucignano, Rosanna (2024) Protein aggregation mechanisms: from amyloid fibrils to the design of new bionanomaterials. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Protein aggregation mechanisms: from amyloid fibrils to the design of new bionanomaterials |
| Autori: | Autore Email Lucignano, Rosanna rosanna.lucignano@unina.it |
| Data: | 11 Marzo 2024 |
| Numero di pagine: | 224 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 36 |
| Coordinatore del Corso di dottorato: | nome email Lombardi, Angelina alombard@unina.it |
| Tutor: | nome email Picone, Delia [non definito] |
| Data: | 11 Marzo 2024 |
| Numero di pagine: | 224 |
| Parole chiave: | aggregation, fibrils, nanocages, proteins, nanomaterials, biotechnology, structural biology |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/03 - Chimica generale e inorganica |
| Depositato il: | 22 Mar 2024 17:31 |
| Ultima modifica: | 16 Mar 2026 10:36 |
| URI: | http://www.fedoa.unina.it/id/eprint/15444 |
Abstract
Protein self-assembly processes play an important role in some severe neurodegenerative disorders, such as Alzheimer and Parkinson diseases. At the same time, the capability of some globular proteins to form ordered aggregates can be exploited to obtain novel nanostructured materials. Protein nanomaterials offer economic and environmental sustainability, due to their easy production, the possibility to fine tune their properties by molecular design and the biocompatibility. Their supramolecular assemblies can be characterized by 1D (fibrillar systems), 2D (films or functionalized surfaces) and 3D (hydrogels or hierarchical structures) dimensionality, thus they are suitable for a plethora of technological applications. This project aims to increase the basic knowledge about the proteins self-assembly properties and their supramolecular structures and to the design and production of novel materials for applications in nanomedicine and nanotechnology.
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