Garifalos, Francesco (2024) Exposure to heavy metals in male residents in the Land of Fires: Epidemiological study on the impact of cadmium on testicular structure, and clinical risk factors of testicular cancer. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Exposure to heavy metals in male residents in the Land of Fires: Epidemiological study on the impact of cadmium on testicular structure, and clinical risk factors of testicular cancer |
| Autori: | Autore Email Garifalos, Francesco francesco.garifalos@gmail.com |
| Data: | 8 Marzo 2024 |
| Numero di pagine: | 20 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Sanità Pubblica |
| Dottorato: | Sanità pubblica e medicina preventiva |
| Ciclo di dottorato: | 36 |
| Coordinatore del Corso di dottorato: | nome email Triassi, Maria maria.triassi@unina.it |
| Tutor: | nome email Pivonello, Rosario [non definito] |
| Data: | 8 Marzo 2024 |
| Numero di pagine: | 20 |
| Parole chiave: | Testicular morpho-structure, testicular hypotrophy, varicocele, testicular cancer, environment, endocrine disruptors, cadmium, Land of Fires, Campania, Italy. |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/13 - Endocrinologia |
| Depositato il: | 15 Mar 2024 08:58 |
| Ultima modifica: | 30 Mar 2026 08:34 |
| URI: | http://www.fedoa.unina.it/id/eprint/15535 |
Abstract
Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration; despite the global scientific concerns related to the general health of residents, current literature is devoid of large studies evaluating, in particular, the incidence of male reproductive disorders and testicular cancer in high environmental impact areas of Campania Region. The heavy metal cadmium (Cd) is a ubiquitous known human carcinogen, and has been consistently shown to affect human male reproductive function by multiple actions, including both endocrine and non-endocrine mechanisms, mostly elucidated in experimental animal models, and suggested to be associated with testicular morphostructural alterations including testicular parenchymal structure inhomogeneity, testicular hypotrophy and varicocele, as well as with testicular solid lesions. The aim of the current single- center, observational, cross-sectional cohort study was to evaluate the prevalence of testicular morphostructural alterations in a large cohort of 465 men (age range:14-50 yrs mean: 29.5±7.23 yrs) living in three municipalities (Acerra, Afragola, Giugliano in Campania) belonging to the high- environmental impact area “Land of Fires” of Campania Region, by addressing the potential association with whole semen Cd (sCd) level, measured in 385 samples by inductively coupled plasma-mass spectrometry. The current study demonstrated for the first time, in a large cohort of adult men living in high-environmental impact areas of Campania Region, a significant association of higher sCd levels with reduced mean testicular volume and higher prevalence of testicular hypotrophy and low grade varicocele, independently from age, BMI and smoking habit, therefore further strengthening the evidence of Cd-related testicular toxicity.
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