Di Pascale, Antonio
(2011)
Alterations of iron metabolism during heart ischemia/reperrfusion injury.
Cytoprotective effects of Simvastatin.
[Tesi di dottorato]
(Inedito)
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Alterations of iron metabolism during heart ischemia/reperrfusion injury.
Cytoprotective effects of Simvastatin. |
| Autori: |
| Autore | Email |
|---|
| Di Pascale, Antonio | antonio.dipascale@unina.it |
|
| Data: |
29 Novembre 2011 |
| Numero di pagine: |
122 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Farmacologia sperimentale |
| Scuola di dottorato: |
Scienze farmaceutiche |
| Dottorato: |
Scienza del farmaco |
| Ciclo di dottorato: |
24 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| D'Auria, Maria Valeria | madauria@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Colonna, Alfredo | alfcolon@unina.it |
|
| Data: |
29 Novembre 2011 |
| Numero di pagine: |
122 |
| Parole chiave: |
Iron metabolism; cardiac ischemia; Simvastatin |
| Settori scientifico-disciplinari del MIUR: |
Area 05 - Scienze biologiche > BIO/14 - Farmacologia
Area 05 - Scienze biologiche > BIO/10 - Biochimica |
[error in script]
[error in script]
| Depositato il: |
06 Dic 2011 11:29 |
| Ultima modifica: |
30 Apr 2014 19:47 |
| URI: |
http://www.fedoa.unina.it/id/eprint/8693 |
| DOI: |
10.6092/UNINA/FEDOA/8693 |
Abstract
Ischemic heart disease, the main cause of mortality and morbidity in industrialized countries, is a metabolic phenomenon due to an inadequate oxygenation of heart tissue caused by the closing or narrowing of the coronary arteries. However, the ischemic condition and the subsequent tissue reperfusion, lead to several functional and metabolic changes that globally define the so-called “ischemia/reperfusion injury”. This injury leads to metabolic and functional alterations, in particular due to the production of the Oxygen Reactive Species (ROS) that are able to promote cell damage. Because iron is involved in the ROS production by the Haber-Weiss-Fenton reaction, the aim of this study was to elucidate the molecular mechanisms underlying the iron metabolism during the cardiac ischemia/reperfusion. To this aim it has been analyzed the activity and the expression of the main proteins involved in iron homeostasis, such as the Iron Regulatory Proteins, Transferrin Receptor 1 (TfR1), and ferritin in an in vivo model of cardiac ischemia/reperfusion.Other aim of this study has been to evaluate the cytoprotective role of the cholesterol-lowering drug Simvastatin, during the ischemic/reperfusion injury, because of its anti-inflammatory and antioxidant effects (“pleiotropic effects”).
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